Gene

foxo3b

ID

ZDB-GENE-990708-6

Name

forkhead box O3b

Symbol

foxo3b Nomenclature History

Previous Names

foxo5
fkhr (1)
wu:fj65a12 (1)
zFkhr (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding activity; and transcription factor binding activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of defense response to virus; and primitive hemopoiesis. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including immune system; liver; nervous system; pericardial region; and posterior lateral mesoderm. Orthologous to human FOXO3 (forkhead box O3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 13 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu663 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With foxo3b Human Ortholog

No data available

Associated With foxo3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR030456	Fork head domain conserved site 2
Domain	IPR001766	Fork head domain
Domain	IPR032067	FOXO protein, transactivation domain
Domain	IPR032068	FOXO protein, KIX-binding domain
Domain	IPR047408	Forkhead box protein O1, forkhead domain
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily