Gene

map3k4

ID

ZDB-GENE-990603-4

Name

mitogen-activated protein kinase kinase kinase 4

Symbol

map3k4 Nomenclature History

Previous Names

mekk4
cb135 (1)
fa02f11
im:7137220
si:ch211-67f13.5
wu:fa02f11

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable ATP binding activity and JUN kinase kinase kinase activity. Predicted to be involved in p38MAPK cascade. Predicted to act upstream of or within MAPK cascade and protein phosphorylation. Is expressed in several structures, including mesoderm; nervous system; neural plate; primordial germ cell; and tail bud. Orthologous to human MAP3K4 (mitogen-activated protein kinase kinase kinase 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb135 (25 images)
IMAGE:7137220 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With map3k4 Human Ortholog

No data available

Associated With map3k4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR045801	Mitogen-activated protein kinase kinase kinase, N-terminal
Family	IPR050538	Mitogen-activated protein kinase kinase kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Mitogen-activated protein kinase kinase kinase	Mitogen-activated protein kinase kinase kinase, N-terminal	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site
UniProtKB:A0A0R4IK63 InterPro	1540
UniProtKB:A0A8M3B5F7 InterPro	1539
UniProtKB:A0A8M9PYS2 InterPro	1505
UniProtKB:A0A8M3AZE2 InterPro	1506

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	map3k4-202 (1) Ensembl	Ensembl	5,567 nt	Select Tool ZFIN BLAST
mRNA	map3k4-203 (1) Ensembl	Ensembl	748 nt	Select Tool ZFIN BLAST
ncRNA	map3k4-002 (1) Ensembl	Ensembl	351 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations