Gene
hspa8
- ID
- ZDB-GENE-990415-92
- Name
- heat shock protein 8
- Symbol
- hspa8 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have several functions, including ATP binding activity; misfolded protein binding activity; and protein folding chaperone. Involved in several processes, including fin regeneration; positive regulation of receptor-mediated endocytosis; and protein localization to early endosome. Predicted to localize to cytosol; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Is expressed in several structures, including head; immature eye; nervous system; otic vesicle; and presumptive neural plate. Orthologous to human HSPA8 (heat shock protein family A (Hsp70) member 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55272 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018181 | Heat shock protein 70, conserved site |
| Family | IPR013126 | Heat shock protein 70 family |
| Homologous_superfamily | IPR029047 | Heat shock protein 70kD, peptide-binding domain superfamily |
| Homologous_superfamily | IPR029048 | Heat shock protein 70kD, C-terminal domain superfamily |
| Homologous_superfamily | IPR043129 | ATPase, nucleotide binding domain |
Domain Details Per Protein
| Protein | Length | ATPase, nucleotide binding domain | Heat shock protein 70, conserved site | Heat shock protein 70 family | Heat shock protein 70kD, C-terminal domain superfamily | Heat shock protein 70kD, peptide-binding domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:Q90473
|
649 | |||||
|
UniProtKB:Q6NYR4
|
649 |
Interactions and Pathways
No data available
Plasmids
No data available