Gene
tcf3a
- ID
- ZDB-GENE-990415-51
- Name
- transcription factor 3a
- Symbol
- tcf3a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables sequence-specific DNA binding activity. Acts upstream of or within striated muscle cell development. Predicted to be part of transcription regulator complex. Is expressed in heart. Human ortholog(s) of this gene implicated in agammaglobulinemia 8A; agammaglobulinemia 8B; and colorectal cancer. Orthologous to human TCF3 (transcription factor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7140653 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Chong et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| agammaglobulinemia 8A | Alliance | Agammaglobulinemia 8A, autosomal dominant | 616941 |
| agammaglobulinemia 8B | Alliance | Agammaglobulinemia 8B, autosomal recessive | 619824 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Neuronal Differentiation E-box Binding Transcription Factors |
|---|---|---|---|---|
|
UniProtKB:Q90491
|
583 |
Interactions and Pathways
No data available
Plasmids
No data available