Gene

tpma

ID

ZDB-GENE-990415-269

Name

alpha-tropomyosin

Symbol

tpma Nomenclature History

Previous Names

tm
fb37a09
TPM1-2 alpha (1)
tropomyosin alpha chain
wu:fb37a09 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable actin filament binding activity; protein heterodimerization activity; and protein homodimerization activity. Acts upstream of or within myeloid cell development. Predicted to be located in actin cytoskeleton. Predicted to be active in actin filament. Is expressed in adaxial cell; male organism; musculature system; pericardial region; and somite. Human ortholog(s) of this gene implicated in congenital fiber-type disproportion; dilated cardiomyopathy 1Y; familial hypertrophic cardiomyopathy; hypertrophic cardiomyopathy 3; and nemaline myopathy 1. Orthologous to several human genes including TPM1 (tropomyosin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

38 figures from 27 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:77897 (17 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Gieger et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tpma Human Ortholog

No data available

Associated With tpma Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR000533	Tropomyosin

Domain Details Per Protein

Protein	Length	Tropomyosin
UniProtKB:P13104 InterPro	284

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tpma-001 (1)	Havana	1,618 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpma-002 (1)	Havana	1,407 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpma-201 (1) Ensembl	Ensembl	812 nt	Select Tool ZFIN BLAST
mRNA	tpma-202 (1) Ensembl	Ensembl	3,089 nt	Select Tool ZFIN BLAST
mRNA	tpma-203 (1) Ensembl	Ensembl	529 nt	Select Tool ZFIN BLAST
mRNA	tpma-204 (1) Ensembl	Ensembl	721 nt	Select Tool ZFIN BLAST
mRNA	tpma-205 (1) Ensembl	Ensembl	487 nt	Select Tool ZFIN BLAST
mRNA	tpma-206 (1) Ensembl	Ensembl	402 nt	Select Tool ZFIN BLAST
mRNA	tpma-207 (1) Ensembl	Ensembl	631 nt	Select Tool ZFIN BLAST
mRNA	tpma-208 (1) Ensembl	Ensembl	751 nt	Select Tool ZFIN BLAST
mRNA	tpma-209 (1) Ensembl	Ensembl	753 nt	Select Tool ZFIN BLAST
mRNA	tpma-210 (1) Ensembl	Ensembl	639 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations