ZFIN ID: ZDB-GENE-990415-256
Gene Name: nodal-related 1
Gene Symbol: ndr1
Previous Names: Ndr-1, Znr-2, znr2, CHUNP6892, sqt, squint
Location: Chr: 21   Details
GENE EXPRESSION
All Expression Data: 46 figures from 36 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  anatomical structure, blastodisc, blastodisc lateral margin, blastomere (all 17) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 39 genotypes
Alleles: cz35, hi975Tg, la021868Tg, ndr1_unspecified, sg27 (all 7) expand
Knockdown reagents: MO1-ndr1 (1), MO2-ndr1 (1), MO3-ndr1 (1), MO4-ndr1 (1), MO5-ndr1 (1) (all 8) expand
PHENOTYPE
Data: 22 figures from 13 publications
Observed in: axis, chorion, diencephalon ventral region, embryonic axis specification (all 23) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Heterotaxy, visceral, 5 270100
GENE ONTOLOGY
Ontology GO Term
Biological Process determination of dorsal identity (more)
Cellular Component extracellular region (more)
Molecular Function growth factor activity (more)
GO Terms (all 22)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001111 (1)
  • InterPro:IPR001839 (1)
  • InterPro:IPR002405 (1)
  • InterPro:IPR015615 (1)
  • InterPro:IPR017948 (1)
  • InterPro:IPR029034 (1)
  • PROSITE:PS00250 (1)
  • PROSITE:PS51362 (1)
  • Pfam:PF00019 (1)
  • Pfam:PF00688 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ndr1-001 (1) 1592
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ndr1
    Tg(ndr1:GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    ndr1 Contained in: [BAC] CH211-220B15 (order this), CH211-263M18 (1) (order this)
    ndr1 Contains: [SNP] rs3729101 (1), rs3729102 (1)
    ndr1 Encodes: [BAC END] zk5k12.sp6
    [cDNA] MGC:114021 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130966 (1) 1480 bp
    Genomic GenBank:BX530056 (1) 235804 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1QDT8 (1) 392 aa
    Sequence Clusters UniGene:20960 (1)
    Sequence Information (all 19)
    OTHER ndr1 GENE PAGES
  • Gene:799352 (1)
  • VEGA:OTTDARG00000021006 (1)
  • Ensembl(Zv9):ENSDARG00000057096 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish ndr1 21  
    Human NODAL 10 (10q22.1)
  • OMIM:601265
  • Gene:4838
  • Mouse Nodal 10 ( 32.21 cM)
  • MGI:97359
  • Gene:18119
  • Orthology Details
    CITATIONS (160)