ZFIN ID: ZDB-GENE-990415-256
Gene Name: nodal-related 1
Gene Symbol: ndr1
Previous Names: Ndr-1, CHUNP6892, sqt, squint, Znr-2, znr2
Location: Chr: 21 Details
GENE EXPRESSION
All Expression Data: 52 figures from 40 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  anatomical structure, blastoderm, blastodisc, blastodisc lateral margin (all 20) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Mutagen Suppliers
cz35 Insertion
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi975Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la021868Tg Transgenic Insertion DNA
    ndr1_unspecified Unspecified
    sg7 Insertion ZINC_FINGER_NUCLEASE
    sg27 Indel TALEN
    sg32 Indel TALEN
    Targeting reagents: CRISPR1-ndr1 (2), MO1-ndr1 (1), MO2-ndr1 (1), MO3-ndr1 (1), MO4-ndr1 (1) (all 9) expand
    PHENOTYPE
    Data: 23 figures from 14 publications
    Observed in: axis, chorion, diencephalon ventral region, embryonic axis specification (all 23) expand
    DISEASE ASSOCIATED WITH ndr1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    situs inversus Heterotaxy, visceral, 5 270100
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of dorsal identity (more)
    Cellular Component extracellular region (more)
    Molecular Function growth factor activity (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001111 (1)
  • InterPro:IPR001839 (1)
  • InterPro:IPR002405 (1)
  • InterPro:IPR015615 (1)
  • InterPro:IPR017948 (1)
  • InterPro:IPR029034 (1)
  • PROSITE:PS00250 (1)
  • PROSITE:PS51362 (1)
  • Pfam:PF00019 (1)
  • Pfam:PF00688 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ndr1-001 (1) 1592
    GENE PRODUCT DESCRIPTION
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM ndr1
    Tg(ndr1:GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    ndr1Contained in: [BAC] CH211-220B15 (order this), CH211-263M18 (1) (order this)
    ndr1Contains: [SNP] rs3729101 (1), rs3729102 (1)
    ndr1Encodes: [BAC END] zk5k12.sp6
    [cDNA] MGC:114021 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130966 (1) 1480bp
    Genomic GenBank:BX530056 (1) 235804bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1QDT8 (1) 392aa
    Sequence Clusters UniGene:20960 (1)
    Sequence Information (all 19)
    OTHER ndr1 GENE PAGES
  • Gene:799352 (1)
  • VEGA:OTTDARG00000021006 (1)
  • Ensembl(GRCz10):ENSDARG00000057096 (1)
  • ORTHOLOGY for ndr1 (Chr: 21)
    Species Symbol Chromosome Accession # Evidence
    Human NODAL 10
  • Gene:4838
  • OMIM:601265
  • HGNC:7865
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Mouse Nodal 10
  • MGI:97359
  • Gene:18119
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (176)