Gene
pparg
- ID
- ZDB-GENE-990415-213
- Name
- peroxisome proliferator-activated receptor gamma
- Symbol
- pparg Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor activity. Acts upstream of or within regulation of lipid metabolic process and triglyceride homeostasis. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including adipose tissue; digestive system; female organism; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal disease; lipodystrophy (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 81 figures from 63 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017619 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ecn6 | Allele with one delins | Exon 2 | Unknown | CRISPR | |
| sa1220 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa1737 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27703 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34999 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35000 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| wi701 | Allele with one delins | Unknown | Unknown | TALEN | |
| zf3729 | Allele with one deletion | Exon 2 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pparg | (3) | |
| CRISPR2-pparg | (2) | |
| CRISPR3-pparg | Emmerich et al., 2023 | |
| CRISPR4-pparg | Emmerich et al., 2023 | |
| MO1-pparg | N/A | Her et al., 2013 |
| MO2-pparg | N/A | O'Hare et al., 2016 |
| MO3-pparg | N/A | Cheng et al., 2019 |
| TALEN1-pparg | Carter et al., 2017 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial partial lipodystrophy type 3 | Alliance | Lipodystrophy, familial partial, type 3 | 604367 |
| obesity | Alliance | Obesity, severe | 601665 |
| type 2 diabetes mellitus | Alliance | Insulin resistance, severe, digenic | 125853 |
| type 2 diabetes mellitus | Alliance | {Diabetes, type 2} | 125853 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR022590 | Peroxisome proliferator-activated receptor gamma, N-terminal |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR003074 | Peroxisome proliferator-activated receptor |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR1 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma | Peroxisome proliferator-activated receptor gamma, N-terminal | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A6XMH6 | InterPro | 527 |
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Interactions and Pathways
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | EST | dq017619 | Bertrand et al., 2007 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131467 (1) | 1994 nt | ||
| Genomic | GenBank:CABZ01061872 (1) | 12450 nt | ||
| Polypeptide | UniProtKB:A6XMH6 (1) | 527 aa |
- Du, Q., Shao, R., Wang, W., Zhang, H., Liao, X., Wang, Z., Yin, Z., Ai, Q., Mai, K., Tang, X., Wan, M. (2024) Vitamin D3 Regulates Energy Homeostasis under Short-Term Fasting Condition in Zebrafish (Danio Rerio). Nutrients. 16(9):
- Gao, S.Y., Zhao, J.C., Xia, Q., Sun, C., Aili, M., Talifu, A., Huo, S.X., Zhang, Y., Li, Z.J. (2024) Evaluation of the hepatotoxicity of Psoralea corylifolia L. based on a zebrafish model. Frontiers in pharmacology. 15:13086551308655
- Gao, Y., Wu, Y., Tie, F., Wang, H. (2024) Stilbenoids from fenugreek seeds alleviate insulin resistance by regulating the PI3K/AKT/mTOR signaling pathway in a type 2 diabetes zebrafish model. Heliyon. 10:e32007e32007
- Kaplan, G., Beler, M., Ünal, I., Karagöz, A., Eğilmezer, G., Üstündağ, Ü.V., Cansız, D., Alturfan, A.A., Emekli-Alturfan, E. (2024) Diethylhexyl phthalate exposure amplifies oxidant and inflammatory response in fetal hyperglycemia model predisposing insulin resistance in zebrafish embryos. Toxicology and industrial health. 40(5):232-243
- Lin, B., Wan, H., Yang, J., Yu, L., Zhou, H., Wan, H. (2024) Lipid regulation of protocatechualdehyde and hydroxysafflor yellow A via AMPK/SREBP2/PCSK9/LDLR signaling pathway in hyperlipidemic zebrafish. Heliyon. 10:e24908e24908
- Tian, Y., Lautrup, S., Law, P.W.N., Dinh, N.D., Fang, E.F., Chan, W.Y. (2024) WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome. Cell & Bioscience. 14:77
- Wang, X., Li, X., Wang, Y., Ren, Z., Du, X., Gao, J., Ji, G., Liu, Z. (2024) Nkx1.2 deletion decreases fat production in zebrafish. Obesity (Silver Spring, Md.). 32(7):1315-1328
- Wu, J., Zhuang, W., Lu, K., Zhang, L., Wang, Y., Chai, F., Liang, X.F. (2024) Study on the Function of Leptin Nutrient Acquisition and Energy Metabolism of Zebrafish (Danio rerio). International Journal of Molecular Sciences. 25(21):
- Yu, H.C., Bai, Q.R., Guo, J.J., Chen, M.Y., Wang, L., Tong, F.C., Zhang, S.L., Wu, J. (2024) Elucidating hydroxysafflor yellow A's multi-target mechanisms against alcoholic liver disease through integrative pharmacology. Phytomedicine : international journal of phytotherapy and phytopharmacology. 134:155956155956
- Yu, W., Luo, R., He, C., Li, Z., Yang, M., Zhou, J., He, J., Chen, Q., Song, Z., Cheng, S. (2024) Bergenin mitigates neuroinflammatory damage induced by high glucose: insights from Zebrafish, murine microbial cell line, and rat models. Frontiers in pharmacology. 15:13391781339178
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