Gene
tdgf1
- ID
- ZDB-GENE-990415-198
- Name
- teratocarcinoma-derived growth factor 1
- Symbol
- tdgf1 Nomenclature History
- Previous Names
-
- cb85 (1)
- cripto
- oep
- one eyed pinhead
- one-eyed pinhead
- wu:fe01d04
- zgc:109829
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable activin receptor binding activity and nodal binding activity. Acts upstream of or within several processes, including embryonic morphogenesis; nervous system development; and regionalization. Located in external side of plasma membrane. Is expressed in several structures, including EVL; cardiovascular system; diencephalon; ectoderm; and mesoderm. Used to study neural tube defect. Human ortholog(s) of this gene implicated in colon cancer and congenital heart disease. Orthologous to human CRIPTO (cripto, EGF-CFC family member).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb85 (38 images)
Wild Type Expression Summary
- All Phenotype Data
- 66 figures from 44 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| neural tube defect | tdgf1m134/m134 | standard conditions | Ma et al., 2015 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cryptic/Cripto, CFC domain | EGF-like domain |
|---|---|---|---|---|
| UniProtKB:F1Q691 | InterPro | 190 | ||
| UniProtKB:A7MCB2 | InterPro | 183 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Pastor-Escuredo, D., Lombardot, B., Savy, T., Boyreau, A., Doursat, R., Goicolea, J.M., Santos, A., Bourgine, P., Del Álamo, J.C., Ledesma-Carbayo, M.J., Peyriéras, N. (2025) Unsupervised spatiotemporal classification of deformation patterns of embryonic tissues matches their fate map. iScience. 28:111753111753
- Čapek, D., Safroshkin, M., Morales-Navarrete, H., Toulany, N., Arutyunov, G., Kurzbach, A., Bihler, J., Hagauer, J., Kick, S., Jones, F., Jordan, B., Müller, P. (2023) EmbryoNet: using deep learning to link embryonic phenotypes to signaling pathways. Nature Methods. 20(6):815-823
- Kuhn, T., Landge, A.N., Mörsdorf, D., Coßmann, J., Gerstenecker, J., Čapek, D., Müller, P., Gebhardt, J.C.M. (2022) Single-molecule tracking of Nodal and Lefty in live zebrafish embryos supports hindered diffusion model. Nature communications. 13:6101
- Li, H., Xu, W., Xiang, S., Tao, L., Fu, W., Liu, J., Liu, W., Xiao, Y., Peng, L. (2022) Defining the Pluripotent Marker Genes for Identification of Teleost Fish Cell Pluripotency During Reprogramming. Frontiers in genetics. 13:819682
- Preiß, H., Kögler, A.C., Mörsdorf, D., Čapek, D., Soh, G.H., Rogers, K.W., Morales-Navarrete, H., Almuedo-Castillo, M., Müller, P. (2022) Regulation of Nodal signaling propagation by receptor interactions and positive feedback. eLIFE. 11:
- Stock, J., Kazmar, T., Schlumm, F., Hannezo, E., Pauli, A. (2022) A self-generated Toddler gradient guides mesodermal cell migration. Science advances. 8:eadd2488
- Truchado-García, M., Perry, K.J., Cavodeassi, F., Kenny, N.J., Henry, J.Q., Grande, C. (2022) A small change with a twist ending - a single residue in EGF-CFC drives Bilaterian asymmetry. Molecular Biology and Evolution. 40(2)
- Truszkowski, L., Batur, D., Long, H., Tarbashevich, K., Vos, B.E., Trappmann, B., Raz, E. (2022) Primordial germ cells adjust their protrusion type while migrating in different tissue contexts in vivo. Development (Cambridge, England). 150(2):
- Alaniz Emig, A., Williams, M.L.K. (2021) Generation of Naïve Blastoderm Explants from Zebrafish Embryos. Journal of visualized experiments : JoVE. (173):
- Guglielmi, L., Heliot, C., Kumar, S., Alexandrov, Y., Gori, I., Papaleonidopoulou, F., Barrington, C., East, P., Economou, A.D., French, P.M.W., McGinty, J., Hill, C.S. (2021) Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways. Nature communications. 12:6374
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