Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-980526-526
Gene Name: wingless-type MMTV integration site family, member 1
Gene Symbol: wnt1
Previous Names: int-1, etID22400.23 (1), sb:eu647, zgc:194464, zgc:194478
Nomenclature History
GENE EXPRESSION
All Expression Data: 70 figures from 46 publications
Directly Submitted Expression Data: 6 figures (26 images) from Thisse et al., 2005 [eu647]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  alar plate midbrain region, cerebellum, diencephalon, epiphysis (all 42) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 3 genotypes
Alleles: w5
Knockdown reagents: MO1-wnt1 (1), MO2-wnt1 (1), MO3-wnt1 (1)
PHENOTYPE
Data: 3 figures from 2 publications
Observed in: cell proliferation in hindbrain, cranial nerve IX, cranial nerve VI, cranial nerve VII (all 12) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Osteogenesis imperfecta, type XV 615220
{Osteoporosis, early-onset, susceptibility to, autosomal dominant} 615221
GENE ONTOLOGY
Ontology GO Term
Biological Process midbrain-hindbrain boundary development (more)
Cellular Component extracellular region (more)
Molecular Function receptor binding (more)
GO Terms (all 34)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR005817 (1)
  • InterPro:IPR009139 (1)
  • InterPro:IPR018161 (1)
  • PROSITE:PS00246 (1)
  • Pfam:PF00110 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA wnt1-001 (1) 1360
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM wnt1
    Tg(-6.6wnt1:Gal4-VP16-6.7wnt1,14xUAS-E1b:EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    wnt1 Contained in: [BAC] DKEY-166N8 (1) (order this)
    wnt1 Encodes: [EST] eu647 (1)
    [cDNA] MGC:194464 (1) (order this), MGC:194478 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001201398 (1) 1360 bp
    Genomic GenBank:CR352210 (1) 180924 bp
    Select Tool
    Polypeptide UniProtKB:F1QUW0 (1) 375 aa
    Sequence Clusters UniGene:85371 (1)
    Sequence Information (all 19)
    OTHER wnt1 GENE PAGES
  • Gene:30128 (1)
  • VEGA:OTTDARG00000028143 (1)
  • Ensembl(Zv9):ENSDARG00000055554 (1)
  • MAPPING INFORMATION
    Chr: 23 Details View Map: Merged   Individual Panels
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish wnt1 23  
    Human WNT1 12 (12q13)
  • OMIM:164820
  • Gene:7471
  • Mouse Wnt1 15 ( 54.65)
  • MGI:98953
  • Gene:22408
  • CITATIONS (116)