Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-980526-488
Gene Name: fibroblast growth factor receptor 4
Gene Symbol: fgfr4
Previous Names: etID309818.21 (1), wu:fc13h10 (1), zgc:111935
Location: Chr: 21   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 17 figures from 16 publications
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
  brain, diencephalon, heart, midbrain (all 14) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 3 genotypes
Alleles: hu3514, hu3582, la022005Tg, sa24004, sa24005
Knockdown reagents: MO1-fgfr4 (1), MO2-fgfr4 (1)
PHENOTYPE
Data: Fig. 10 from Nakayama et al., 2008
Observed in: optic cup, solid lens vesicle

Phenotype of Human Orthologue OMIM Phenotype ID
{Cancer progression/metastasis}
GENE ONTOLOGY
Ontology GO Term
Biological Process fibroblast growth factor receptor signaling pathway (more)
Cellular Component endoplasmic reticulum (more)
Molecular Function protein binding (more)
GO Terms (all 20)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013151 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR016248 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF00047 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA fgfr4-001 (1) 5011
    ncRNA fgfr4-002 (1) 3229
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fgfr4 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    fgfr4 Contained in: [BAC] CH211-281E1 (1) (order this), DKEY-53B2 (1)
    fgfr4 Contains: [BAC END] zc120k11.ya (1)
    fgfr4 Encodes: [EST] fc13h10 (1)
    [cDNA] cssl:d109 (1), MGC:198431 (1) (order this)
    fgfr4 Has Artifact: [cDNA] MGC:111935 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131430 (1) 4705 bp
    Genomic GenBank:BX649250 (1) 165729 bp
    Select Tool
    Polypeptide UniProtKB:B7ZVT9 (1) 922 aa
    Sequence Clusters UniGene:75058 (1)
    Sequence Information (all 22)
    OTHER fgfr4 GENE PAGES
  • Gene:100000160 (1)
  • VEGA:OTTDARG00000021085 (1)
  • Ensembl(Zv9):ENSDARG00000069105 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish fgfr4 21  
    Human FGFR4 5 (5q35.2)
  • OMIM:134935
  • Gene:2264
  • Mouse Fgfr4 13 ( 29.80 cM)
  • MGI:95525
  • Gene:14186
  • Orthology Details
    CITATIONS (70)