ZFIN ID: ZDB-GENE-980526-488
Gene Name: fibroblast growth factor receptor 4
Gene Symbol: fgfr4

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Previous Names: etID309818.21 (1), wu:fc13h10 (1), zgc:111935

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(Including Attributions)
Location: Chr: 21 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 25 figures from 23 publications
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
  anatomical structure, brain, caudal vein plexus, cephalic musculature (all 39) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3514 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hu3582 Unknown Unknown Unknown ENU
    la022005Tg Transgenic Insertion Unknown Unknown DNA
    sa6682 Point Mutation Unknown Premature Stop ENU
    sa24004 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24005 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37357 Point Mutation Unknown Premature Stop ENU
    Targeting reagents: CRISPR1-fgfr4 (1), CRISPR2-fgfr4 (1), MO1-fgfr4 (1), MO2-fgfr4 (1)
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in: heart, hindbrain, optic cup, solid lens vesicle (all 5) expand
    DISEASE ASSOCIATED WITH fgfr4 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    {Cancer progression/metastasis}
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fibroblast growth factor receptor signaling pathway (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function protein binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013151 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR016248 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF00047 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA fgfr4-001 (1) 5011
    ncRNA fgfr4-002 (1) 3229
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM fgfr4 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    fgfr4Contained in: [BAC] CH211-281E1 (1) (order this), DKEY-53B2 (1) (order this)
    fgfr4Contains: [BAC END] zc120k11.ya (1)
    fgfr4Encodes: [EST] fc13h10 (1)
    [cDNA] cssl:d109 (1), MGC:198431 (1) (order this)
    fgfr4Has Artifact: [cDNA] MGC:111935 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131430 (1) 4705bp
    Genomic GenBank:BX649250 (1) 165729bp
    Select Tool
    Polypeptide UniProtKB:B7ZVT9 (1) 922aa
    Sequence Clusters UniGene:75058 (1)
    Sequence Information (all 22)
    OTHER fgfr4 GENE PAGES
  • Gene:100000160 (1)
  • VEGA:OTTDARG00000021085 (1)
  • Ensembl(GRCz10):ENSDARG00000069105 (1)
  • ORTHOLOGY for fgfr4 (Chr: 21)
    Species Symbol Chromosome Accession # Evidence
    Human FGFR4 5
  • Gene:2264
  • OMIM:134935
  • HGNC:3691
  • Amino acid sequence comparison (5)
    Conserved genome location (synteny) (2)
    Mouse Fgfr4 13
  • MGI:95525
  • Gene:14186
  • Amino acid sequence comparison (3)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (79)