ZFIN ID: ZDB-GENE-980526-474
Gene Name: bone morphogenetic protein 2b
Gene Symbol: bmp2b
Previous Names: bmp2-4, zbmp-2, zbmp2, cb670 (1), etID309839.20 (1), swirl, swr
Location: Chr: 20 Mapping Details/Browsers
GENE EXPRESSION
All Expression Data: 135 figures from 99 publications
Directly Submitted Expression Data: 6 figures (47 images) from Thisse et al., 2001 [cb670]
Wild-type Stages, Structures: Blastula:Sphere (4.0h-4.33h) to Adult (90d-730d, breeding adult)
  anal fin, anatomical structure, anterior crista primordium, apical ectodermal ridge pectoral fin bud (all 75) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bmp2b_unspecified Unspecified Unknown Unknown
sa18243 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • ta72a Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tc300a Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tdc24 Point Mutation Unknown Premature Stop
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: MO1-bmp2b (1), MO2-bmp2b (1), MO3-bmp2b (1), MO4-bmp2b (1), MO5-bmp2b (1)
    PHENOTYPE
    Data: 32 figures from 20 publications
    Observed in: adaxial cell, axis, cardiac ventricle myofibril, caudal fin ventral region (all 41) expand
    DISEASE ASSOCIATED WITH bmp2b HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    brachydactyly Brachydactyly, type A2 112600
    hemochromatosis {HFE hemochromatosis, modifier of} 235200
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of ventral identity (more)
    Cellular Component extracellular region (more)
    Molecular Function protein homodimerization activity (more)
    GO Terms (all 34)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001111 (1)
  • InterPro:IPR001839 (1)
  • InterPro:IPR002405 (1)
  • InterPro:IPR015615 (1)
  • InterPro:IPR017948 (1)
  • InterPro:IPR029034 (1)
  • PROSITE:PS00250 (1)
  • PROSITE:PS51362 (1)
  • Pfam:PF00019 (1)
  • Pfam:PF00688 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA bmp2b-001 (1) 1961
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM bmp2b
    Tg(hsp70l:bmp2b), Tg(UAS:bmp2b-UTRnanos3), Tg1(hsp70l:bmp2b)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    bmp2bContained in: [BAC] CH211-213I16 (1) (order this)
    bmp2bEncodes: [EST] cb670 (1)
    [cDNA] MGC:92556 (1) (order this), MGC:136722 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131360 (1) 1732bp
    Genomic GenBank:AL929237 (1) 205393bp Blast at MegaBLAST
    Polypeptide UniProtKB:O13108 (1) 411aa
    Sequence Clusters UniGene:568 (1)
    Sequence Information (all 24)
    OTHER bmp2b GENE PAGES
  • Gene:30632 (1)
  • VEGA:OTTDARG00000006906 (1)
  • Ensembl(GRCz10):ENSDARG00000041430 (1)
  • ORTHOLOGY for bmp2b (Chr: 20)
    Species Symbol Chromosome Accession # Evidence
    Human BMP2 20
  • Gene:650
  • OMIM:112261
  • HGNC:1069
  • Amino acid sequence comparison (3)
    Conserved genome location (synteny) (1)
    Mouse Bmp2 2
  • MGI:88177
  • Gene:12156
  • Amino acid sequence comparison (2)
    Download Curated Orthology
    CITATIONS (302)