Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-980526-474
Gene Name: bone morphogenetic protein 2b
Gene Symbol: bmp2b
Previous Names: bmp2-4, zbmp-2, zbmp2, cb670 (1), etID309839.20 (1), swirl, swr
Location: Chr: 20   Details
GENE EXPRESSION
All Expression Data: 120 figures from 86 publications
Directly Submitted Expression Data: 6 figures (47 images) from Thisse et al., 2001 [cb670]
Wild-type Stages, Structures: Blastula:Sphere (4.0h-4.33h) to Adult (90d-730d, breeding adult)
  anal fin, anterior crista primordium, apical ectodermal ridge pectoral fin bud, axis (all 61) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 22 genotypes
Alleles: bmp2b_unspecified, sa18243, ta72a, tc300a, tdc24
Knockdown reagents: MO1-bmp2b (1), MO2-bmp2b (1), MO3-bmp2b (1), MO4-bmp2b (1), MO5-bmp2b (1)
PHENOTYPE
Data: 24 figures from 15 publications
Observed in: adaxial cell, axis, cardiac ventricle myofibril, caudal fin ventral region (all 34) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Brachydactyly, type A2 112600
{HFE hemochromatosis, modifier of} 235200
GENE ONTOLOGY
Ontology GO Term
Biological Process determination of ventral identity (more)
Cellular Component extracellular region (more)
Molecular Function protein homodimerization activity (more)
GO Terms (all 21)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001111 (1)
  • InterPro:IPR001839 (1)
  • InterPro:IPR002405 (1)
  • InterPro:IPR015615 (1)
  • InterPro:IPR017948 (1)
  • InterPro:IPR029034 (1)
  • PROSITE:PS00250 (1)
  • PROSITE:PS51362 (1)
  • Pfam:PF00019 (1)
  • Pfam:PF00688 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA bmp2b-001 (1) 1961
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM bmp2b
    Tg(hsp70l:bmp2b), Tg1(hsp70l:bmp2b)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    bmp2b Contained in: [BAC] CH211-213I16 (1) (order this)
    bmp2b Encodes: [EST] cb670 (1)
    [cDNA] MGC:92556 (1) (order this), MGC:136722 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131360 (1) 1732 bp
    Genomic GenBank:AL929237 (1) 205393 bp Blast at MegaBLAST
    Polypeptide UniProtKB:O13108 (1) 411 aa
    Sequence Clusters UniGene:568 (1)
    Sequence Information (all 22)
    OTHER bmp2b GENE PAGES
  • Gene:30632 (1)
  • VEGA:OTTDARG00000006906 (1)
  • Ensembl(Zv9):ENSDARG00000041430 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish bmp2b 20  
    Human BMP2 20 (20p12)
  • OMIM:112261
  • Gene:650
  • Mouse Bmp2 2 ( 65.21 cM)
  • MGI:88177
  • Gene:12156
  • Orthology Details
    CITATIONS (263)