Gene

foxa2

ID
ZDB-GENE-980526-404
Name
forkhead box A2
Symbol
foxa2 Nomenclature History
Previous Names
  • ax
  • axl
  • axial (1)
  • etID309811.17 (1)
  • fkd1 (1)
  • HNF-3B
  • hnf3b
  • ik:tdsubc_2g8
  • mol
  • monorail
  • tdsubc_2g8
  • wu:fe05g04 (1)
  • xx:tdsubc_2g8
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Enables transcription cis-regulatory region binding activity. Acts upstream of or within axial mesoderm morphogenesis; endoderm development; and nervous system development. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; digestive system; endoderm; mesoderm; and swim bladder. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human FOXA2 (forkhead box A2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
155 figures from 123 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
st20Allele with one point mutationUnknownPremature StopENU
tv53aAllele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-foxa2N/A (8)
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Human Disease
Associated With foxa2 Human Ortholog
No data available
Associated With foxa2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018122 Fork head domain conserved site1
Conserved_site IPR030456 Fork head domain conserved site 2
Domain IPR001766 Fork head domain
Domain IPR013638 Fork-head N-terminal
Domain IPR018533 Forkhead box protein, C-terminal
1 - 5 of 8 Show all
Domain Details Per Protein
Protein Length Forkhead box domain-containing protein Forkhead box protein, C-terminal Fork head domain Fork head domain conserved site1 Fork head domain conserved site 2 Fork-head N-terminal Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:Q07342 409
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 17
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA foxa2-201 (1) Ensembl 1,772 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
TgBAC(foxa2:Kaede)
  • foxa2
  • Danio rerio
1Utsumi et al., 2024
Tg(foxa2-E1B:EGFP)
  • Danio rerio
1 (2)
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-208C12ZFIN Curated Data
EncodesESTfe05g04ZFIN Curated Data
EncodesESTtdsubc_2g8
EncodescDNAMGC:101552ZFIN Curated Data
EncodescDNAMGC:192923ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanFOXA220
Amino acid sequence comparison (4)
Conserved genome location (synteny) (1)
Phylogenetic tree (1)
MouseFoxa22
Amino acid sequence comparison (5)
Phylogenetic tree (2)
Fruit flyfkh3R
Amino acid sequence comparison (1)
Citations
1 - 10 of 262
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