Gene
foxa2
- ID
- ZDB-GENE-980526-404
- Name
- forkhead box A2
- Symbol
- foxa2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables transcription cis-regulatory region binding activity. Acts upstream of or within axial mesoderm morphogenesis; endoderm development; and nervous system development. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; digestive system; endoderm; mesoderm; and swim bladder. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human FOXA2 (forkhead box A2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 155 figures from 123 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Forkhead box domain-containing protein | Forkhead box protein, C-terminal | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Fork-head N-terminal | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q07342
|
409 |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
TgBAC(foxa2:Kaede) |
|
| 1 | Utsumi et al., 2024 | |
Tg(foxa2-E1B:EGFP) |
|
| 1 | (2) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-208C12 | ZFIN Curated Data | |
Encodes | EST | fe05g04 | ZFIN Curated Data | |
Encodes | EST | tdsubc_2g8 | ||
Encodes | cDNA | MGC:101552 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192923 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_130949 (1) | 1712 nt | ||
Genomic | GenBank:CR628331 (2) | 92644 nt | ||
Polypeptide | UniProtKB:Q07342 (1) | 409 aa |
- Utsumi, H., Yabe, T., Koshida, S., Yamashita, A., Takada, S. (2024) Deficiency of mastl, a mitotic regulator, results in cell detachment from developing tissues of zebrafish embryos. Frontiers in cell and developmental biology. 12:13756551375655
- Xu, Y., Zhang, S., Bao, Y., Luan, J., Fu, Z., Sun, M., Zhao, X., Feng, X. (2024) Melatonin protects zebrafish pancreatic development and physiological rhythms from sodium propionate-induced disturbances via the hypothalamic-pituitary-thyroid axis. Journal of the science of food and agriculture. 104(12):7454-7463
- Brown, W., Wesalo, J., Samanta, S., Luo, J., Caldwell, S.E., Tsang, M., Deiters, A. (2023) Genetically Encoded Aminocoumarin Lysine for Optical Control of Protein-Nucleotide Interactions in Zebrafish Embryos. ACS Chemical Biology. 18(6):1305-1314
- Nurcombe, Z.W., Hehr, C.L., McFarlane, S. (2023) Plexina4 and cell survival in the developing zebrafish hindbrain. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(11):1323-1337
- Gao, Y., Jin, Q., Gao, C., Chen, Y., Sun, Z., Guo, G., Peng, J. (2022) Unraveling Differential Transcriptomes and Cell Types in Zebrafish Larvae Intestine and Liver. Cells. 11(20):
- Kang, Q., Zheng, J., Jia, J., Xu, Y., Bai, X., Chen, X., Zhang, X.K., Wong, F.S., Zhang, C., Li, M. (2022) Disruption of the glucagon receptor increases glucagon expression beyond α-cell hyperplasia in zebrafish. The Journal of biological chemistry. 298(12):102665
- Vijayanathan, Y., Hamzah, N.M., Lim, S.M., Lim, F.T., Tan, M.P., Majeed, A.B.A., Ramasamy, K. (2022) Newly regenerated dopaminergic neurons IN 6-OHDA-lesioned adult zebrafish brain proliferate in the Olfactory bulb and telencephalon, but migrate to, differentiate and mature in the diencephalon. Brain research bulletin. 190:218-233
- Jung, J., Kim, J., Huh, T.L., Rhee, M. (2021) Trim46 contributes to the midbrain development via Sonic Hedgehog signaling pathway in zebrafish embryos. Animal cells and systems. 25:56-64
- Liu, K.C., Villasenor, A., Bertuzzi, M., Schmitner, N., Radros, N., Rautio, L., Mattonet, K., Matsuoka, R.L., Reischauer, S., Stainier, D.Y., Andersson, O. (2021) Insulin-producing β-cells regenerate ectopically from a mesodermal origin under the perturbation of hemato-endothelial specification. eLIFE. 10:
- Liu, M., Zhang, W., Li, M., Feng, J., Kuang, W., Chen, X., Yang, F., Sun, Q., Xu, Z., Hua, J., Yang, C., Liu, W., Shu, Q., Yang, Y., Zhou, T., Xie, S. (2021) NudCL2 is an autophagy receptor that mediates selective autophagic degradation of CP110 at mother centrioles to promote ciliogenesis. Cell Research. 31(11):1199-1211
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