ZFIN ID: ZDB-GENE-980526-403
Gene Name: NK2 homeobox 2a
Gene Symbol: nkx2.2a
Previous Names: nk2.2, nkx2-2, nkx2.2, id:ibd5090 (1), wu:fc83b01, zgc:136536
Location: Chr: 17 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 137 figures from 84 publications
Directly Submitted Expression Data: 3 figures (3 images) from Kudoh et al., 2001 [ibd5090]
  6 figures (8 images) from Thisse et al., 2004 [IMAGE:6912071]
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Adult (90d-730d, breeding adult)
  adenohypophyseal placode, anatomical structure, anterior neural keel, anterior pancreatic bud (all 79) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Targeting reagents: MO1-nkx2.2a (1), MO2-nkx2.2a (1), MO3-nkx2.2a (1), MO4-nkx2.2a (1), MO5-nkx2.2a (1) (all 6) expand
PHENOTYPE
Data: 13 figures from 5 publications
Observed in: endocrine pancreas, endocrine pancreas development, floor plate formation, fourth ventricle (all 23) expand
DISEASE ASSOCIATED WITH nkx2.2a HUMAN ORTHOLOGNo data available
GENE ONTOLOGY
Ontology GO Term
Biological Process ventral spinal cord interneuron differentiation (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • InterPro:IPR020479 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA nkx2.2a-001 (1) 1730
    nkx2.2a-002 (1) 1555
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM nkx2.2a
    Tg(-3.5nkx2.2a:GFP), Tg(-8.5nkx2.2a:GFP), Tg(nkx2.2a:mEGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    nkx2.2aContained in: [BAC] DKEY-89L19 (1) (order this)
    nkx2.2aEncodes: [EST] fc83b01 (1), ibd5090 (1) (order this), IMAGE:6912071 (1) (order this)
    [cDNA] MGC:100783 (1) (order this), MGC:136536 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001308640 (1) 1733bp
    Genomic GenBank:BX927409 (1) 154287bp
    Select Tool
    Polypeptide UniProtKB:F1QNE4 (1) 273aa
    Sequence Clusters UniGene:75083 (1)
    Sequence Information (all 21)
    OTHER nkx2.2a GENE PAGES
  • Gene:30697 (1)
  • VEGA:OTTDARG00000020535 (1)
  • Ensembl(GRCz10):ENSDARG00000053298 (1)
  • ORTHOLOGY for nkx2.2a (Chr: 17)
    Species Symbol Chromosome Accession # Evidence
    Human NKX2-2 20
  • Gene:4821
  • OMIM:604612
  • HGNC:7835
  • Amino acid sequence comparison (4)
    Mouse Nkx2-2 2
  • MGI:97347
  • Gene:18088
  • Amino acid sequence comparison (5)
    Download Curated Orthology
    CITATIONS (145)