ZFIN Gene: nkx2.2a

ZFIN ID: ZDB-GENE-980526-403

Gene Name:	NK2 transcription factor related 2a
Gene Symbol:	nkx2.2a
Previous Names:	nk2.2, nkx2-2, nkx2.2, id:ibd5090 (1), wu:fc83b01, zgc:136536
Nomenclature History

GENE EXPRESSION
All Expression Data:	96 figures from 55 publications
Directly Submitted Expression Data:	3 figures (3 images) from Kudoh et al., 2001 [ibd5090]
	6 figures (8 images) from Thisse et al., 2004 [IMAGE:6912071]
Wild-type Stages, Structures:	Gastrula:75%-epiboly (8.0h-9.0h) to Adult (90d-730d, breeding adult)
	adenohypophyseal placode , anterior pancreatic bud , basal plate midbrain region , brain (all 52)
Curated Microarray Expression:	GEO (1)

MUTANTS AND TARGETED KNOCKDOWNS

Knockdown reagents:

MO1-nkx2.2a (1), MO2-nkx2.2a (1), MO3-nkx2.2a (1), MO4-nkx2.2a (1), MO5-nkx2.2a (1) (all 6) expand

PHENOTYPE

Data:	13 figures from 5 publications
Observed in:	endocrine pancreas , endocrine pancreas development , floor plate formation , fourth ventricle (all 23)

GENE ONTOLOGY

Ontology	GO Term
Biological Process	ventral spinal cord interneuron differentiation (more)
Cellular Component	nucleus (more)
Molecular Function	DNA binding (more)

GO Terms (all 15)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR001356 (1) InterPro:IPR009057 (1) InterPro:IPR017970 (1) InterPro:IPR020479 (1)	PROSITE:PS00027 (1) PROSITE:PS50071 (1)	Pfam:PF00046 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	nkx2.2a-001 (1)	1730	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT Vega
	nkx2.2a-002 (1)	1555	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT Vega

GENE PRODUCT DESCRIPTION

ANTIBODIES No data available

CONSTRUCTS WITH SEQUENCES FROM nkx2.2a

Tg(-3.5nkx2.2a:GFP), Tg(-8.5nkx2.2a:GFP), Tg(nkx2.2a:mEGFP)

SEGMENT (CLONE AND PROBE) RELATIONSHIPS

nkx2.2a Contained in:	[BAC] DKEY-89L19 (1) (order this)
nkx2.2a Encodes:	[EST] fc83b01 (1), ibd5090 (1) (order this), IMAGE:6912071 (1) (order this) [cDNA] MGC:100783 (1) (order this), MGC:136536 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131422 (1)	1576 bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT Vega
Genomic	GenBank:BX927409 (1)	154287 bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F1QNE4 (1)	273 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast Vega Protein Blast
Sequence Clusters	UniGene:75083 (1)

OTHER nkx2.2a GENE PAGES

Gene:30697 (1)

VEGA:OTTDARG00000020535 (1)

Ensembl(Zv9):ENSDARG00000053298 (1)

MAPPING INFORMATION
Chr: 17 Details	View Map: Merged Individual Panels

ORTHOLOGY

CITATIONS (116)