Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-980526-403
Gene Name: NK2 transcription factor related 2a
Gene Symbol: nkx2.2a
Previous Names: nk2.2, nkx2-2, nkx2.2, id:ibd5090 (1), wu:fc83b01, zgc:136536
Nomenclature History
GENE EXPRESSION
All Expression Data: 104 figures from 61 publications
Directly Submitted Expression Data: 3 figures (3 images) from Kudoh et al., 2001 [ibd5090]
  6 figures (8 images) from Thisse et al., 2004 [IMAGE:6912071]
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Adult (90d-730d, breeding adult)
  adenohypophyseal placode, anterior pancreatic bud, basal plate midbrain region, brain (all 55) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-nkx2.2a (1), MO2-nkx2.2a (1), MO3-nkx2.2a (1), MO4-nkx2.2a (1), MO5-nkx2.2a (1) (all 6) expand
PHENOTYPE
Data: 13 figures from 5 publications
Observed in: endocrine pancreas, endocrine pancreas development, floor plate formation, fourth ventricle (all 23) expand
GENE ONTOLOGY
Ontology GO Term
Biological Process ventral spinal cord interneuron differentiation (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • InterPro:IPR020479 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA nkx2.2a-001 (1) 1730
    nkx2.2a-002 (1) 1555
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM nkx2.2a
    Tg(-3.5nkx2.2a:GFP), Tg(-8.5nkx2.2a:GFP), Tg(nkx2.2a:mEGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    nkx2.2a Contained in: [BAC] DKEY-89L19 (1)
    nkx2.2a Encodes: [EST] fc83b01 (1), ibd5090 (1) (order this), IMAGE:6912071 (1) (order this)
    [cDNA] MGC:100783 (1) (order this), MGC:136536 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131422 (1) 1576 bp
    Genomic GenBank:BX927409 (1) 154287 bp
    Select Tool
    Polypeptide UniProtKB:F1QNE4 (1) 273 aa
    Sequence Clusters UniGene:75083 (1)
    Sequence Information (all 19)
    OTHER nkx2.2a GENE PAGES
  • Gene:30697 (1)
  • VEGA:OTTDARG00000020535 (1)
  • Ensembl(Zv9):ENSDARG00000053298 (1)
  • MAPPING INFORMATION
    Chr: 17 Details View Map: Merged   Individual Panels
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA
    Zebrafish nkx2.2a 17  
    Human NKX2-2 20 (20p11.22)
  • OMIM:604612
  • Gene:4821
  • Mouse Nkx2-2 2 ( 72.63 cM)
  • MGI:97347
  • Gene:18088
  • CITATIONS (126)