Gene
nkx2.2a
- ID
- ZDB-GENE-980526-403
- Name
- NK2 homeobox 2a
- Symbol
- nkx2.2a Nomenclature History
- Previous Names
-
- nk2.2
- nkx2-2
- nkx2.2
- id:ibd5090 (1)
- wu:fc83b01
- zgc:136536
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of DNA-templated transcription. Acts upstream of or within endocrine pancreas development; floor plate formation; and neurogenesis. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; nervous system; neural keel; neural rod; and neural tube. Orthologous to human NKX2-2 (NK2 homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 153 figures from 98 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6912071 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox NK-like transcription regulators | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|
|
UniProtKB:Q90481
|
269 | |||||
|
UniProtKB:F1QNE4
|
273 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nkx2.2a-201
(1)
|
Ensembl | 1,555 nt | ||
| mRNA |
nkx2.2a-202
(1)
|
Ensembl | 1,730 nt | ||
| mRNA |
nkx2.2a-203
(1)
|
Ensembl | 4,321 nt | ||
| mRNA |
nkx2.2a-204
(1)
|
Ensembl | 4,557 nt | ||
| mRNA |
nkx2.2a-205
(1)
|
Ensembl | 1,550 nt |
Interactions and Pathways
No data available
Plasmids
No data available