Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-980526-400
Gene Name: orthodenticle homeobox 1b
Gene Symbol: otx1b
Previous Names: otx1, zOtx1 (1), cb769 (1), fj99f05 (1), wu:fj99f05
Location: Chr: 17   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 42 figures from 27 publications
Directly Submitted Expression Data: 6 figures (22 images) from Thisse et al., 2001 [cb769]
Wild-type Stages, Structures: Blastula:128-cell (2.25h-2.5h) to Larval:Day 4 (96.0h-120.0h)
  alar plate midbrain region, anterior axial hypoblast, axial hypoblast, axis (all 49) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 3 genotypes
Alleles: sa96, tud37Gt
Knockdown reagents: MO1-otx1b (1), MO2-otx1b (1), MO3-otx1b (1), MO4-otx1b (1)
PHENOTYPE
Data: 2 figures from 2 publications
Observed in: anterior macula, eye, forebrain, inner ear (all 9) expand
GENE ONTOLOGY
Ontology GO Term
Biological Process retinal pigment epithelium development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR003025 (1)
  • InterPro:IPR003026 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR013851 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • Pfam:PF03529 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA otx1b-001 (1) 2513
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM otx1b
    Tg1(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-otx1b-LOXP-gata2a:EGFP-5HS4), Tg2(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-otx1b-LOXP-gata2a:EGFP-5HS4), Tg3(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-otx1b-LOXP-gata2a:EGFP-5HS4)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    otx1b Contained in: [BAC] DKEYP-74F1 (1)
    otx1b Encodes: [EST] cb769 (1) (order this), fj99f05
    [cDNA] MGC:55275 (1) (order this), MGC:191298 (1) (order this)
    otx1b Has Artifact: [EST] IMAGE:5612640
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131250 (1) 2539 bp
    Genomic GenBank:BX649529 (1) 216647 bp Blast at MegaBLAST
    Polypeptide UniProtKB:B2GNW8 (1) 323 aa
    Sequence Clusters UniGene:30626 (1)
    Sequence Information (all 22)
    OTHER otx1b GENE PAGES
  • Gene:30500 (1)
  • VEGA:OTTDARG00000020212 (1)
  • Ensembl(Zv9):ENSDARG00000094992 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish otx1b 17  
    Human OTX1 2 (2p13)
  • OMIM:600036
  • Gene:5013
  • Mouse Otx1 11 ( 14.10 cM)
  • MGI:97450
  • Gene:18423
  • Orthology Details
    CITATIONS (78)