ZFIN ID: ZDB-GENE-980526-400
Gene Name: orthodenticle homeobox 1b
Gene Symbol: otx1b
Previous Names: otx1, zOtx1 (1), cb769 (1), fj99f05 (1), wu:fj99f05
Location: Chr: 17 Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 52 figures from 30 publications
Directly Submitted Expression Data: 6 figures (22 images) from Thisse et al., 2001 [cb769]
Wild-type Stages, Structures: Blastula:128-cell (2.25h-2.5h) to Larval:Day 4 (96.0h-120.0h)
  alar plate midbrain region, anterior axial hypoblast, axial hypoblast, axial mesoderm (all 59) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Mutagen Suppliers
sa96 Point Mutation ENU
tud37Gt Transgenic Insertion DNA
Targeting reagents: MO1-otx1b (1), MO2-otx1b (1), MO3-otx1b (1), MO4-otx1b (1)
PHENOTYPE
Data: 3 figures from 3 publications
Observed in: anterior macula, eye, forebrain, heart (all 12) expand
DISEASE ASSOCIATED WITH otx1b HUMAN ORTHOLOGNo data available
GENE ONTOLOGY
Ontology GO Term
Biological Process retinal pigment epithelium development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR003025 (1)
  • InterPro:IPR003026 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR013851 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • Pfam:PF03529 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA otx1b-001 (1) 2513
    GENE PRODUCT DESCRIPTION
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM otx1b
    Tg1(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-otx1b-LOXP-gata2a:EGFP-5HS4), Tg2(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-otx1b-LOXP-gata2a:EGFP-5HS4), Tg3(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-otx1b-LOXP-gata2a:EGFP-5HS4)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    otx1bContained in: [BAC] DKEYP-74F1 (1)
    otx1bEncodes: [EST] cb769 (1) (order this), fj99f05
    [cDNA] MGC:55275 (1) (order this), MGC:191298 (1) (order this)
    otx1bHas Artifact: [EST] IMAGE:5612640
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131250 (1) 2539bp
    Genomic GenBank:BX649529 (1) 216647bp Blast at MegaBLAST
    Polypeptide UniProtKB:B2GNW8 (1) 323aa
    Sequence Clusters UniGene:30626 (1)
    Sequence Information (all 22)
    OTHER otx1b GENE PAGES
  • Gene:30500 (1)
  • VEGA:OTTDARG00000020212 (1)
  • Ensembl(GRCz10):ENSDARG00000094992 (1)
  • ORTHOLOGY for otx1b (Chr: 17)
    Species Symbol Chromosome Accession # Evidence
    Human OTX1 2
  • Gene:5013
  • OMIM:600036
  • HGNC:8521
  • Amino acid sequence comparison (3)
    Conserved genome location (synteny) (1)
    Mouse Otx1 11
  • MGI:97450
  • Gene:18423
  • Amino acid sequence comparison (3)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (84)