Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-980526-352
Gene Name: wingless-type MMTV integration site family, member 4a
Gene Symbol: wnt4a
Previous Names: wnt4, ZfWnt4 (1), zgc:136737
Nomenclature History
GENE EXPRESSION
All Expression Data: 20 figures from 11 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2005 [eu648]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  alar plate midbrain region, diencephalon, epiphysis, floor plate (all 25) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 5 genotypes
Alleles: fh294, fh295, wnt4a_unrecovered
Knockdown reagents: MO1-wnt4a (1), MO2-wnt4a (1), MO3-wnt4a (1), MO4-wnt4a (1)
PHENOTYPE
Data: 2 figures from 2 publications
Observed in: convergent extension, habenular commissure

Phenotype of Human Orthologue OMIM Phenotype ID
Mullerian aplasia and hyperandrogenism 158330
SERKAL syndrome 611812
GENE ONTOLOGY
Ontology GO Term
Biological Process positive regulation of transcription, DNA-dependent (more)
Cellular Component extracellular region (more)
Molecular Function receptor binding (more)
GO Terms (all 30)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR005817 (1)
  • InterPro:IPR009142 (1)
  • InterPro:IPR018161 (1)
  • PROSITE:PS00246 (1)
  • Pfam:PF00110 (1)
  •  Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM wnt4a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    wnt4a Contained in: [BAC] DKEY-208K8 (1) (order this)
    wnt4a Contains: [SNP] rs3728403 (1)
    wnt4a Encodes: [EST] eu648 (1)
    [cDNA] MGC:136737 (1) (order this), MGC:194977 (1) (order this), MGC:194994 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001040387 (1) 2264 bp
    Genomic GenBank:CR926911 158622 bp
    Select Tool
    Polypeptide UniProtKB:Q1RLW9 (1) 352 aa
    Sequence Clusters UniGene:385 (1)
    Sequence Information (all 20)
    OTHER wnt4a GENE PAGES
  • Gene:30123 (1)
  • Ensembl(Zv9):ENSDARG00000071208 (1)
  • MAPPING INFORMATION
    Chr: 11 Details View Map: Merged   Individual Panels
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL CE
    Zebrafish wnt4a 11  
    Human WNT4 1 (1p36.23-p35.1)
  • OMIM:603490
  • Gene:54361
  • Mouse Wnt4 4 ( 69.80)
  • MGI:98957
  • Gene:22417
  • CITATIONS (40)