Gene
hbbe3
- ID
- ZDB-GENE-980526-287
- Name
- hemoglobin beta embryonic-3
- Symbol
- hbbe3 Nomenclature History
- Previous Names
-
- [b]e3globin
- beta e3 globin (1)
- zgc:110736
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Predicted to be involved in hydrogen peroxide catabolic process. Predicted to act upstream of or within oxygen transport. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in erythroid lineage cell; hematopoietic system; mesoderm; presumptive blood; and vasculature. Human ortholog(s) of this gene implicated in sickle cell anemia. Orthologous to human HBE1 (hemoglobin subunit epsilon 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 81 figures from 56 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Globin | Globin-like superfamily | Globin/Protoglobin | Hemoglobin and related oxygen transporters | Hemoglobin, beta-type |
|---|---|---|---|---|---|---|
|
UniProtKB:Q5BLF6
|
147 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-218L14 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110736 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001015058 (1) | 474 nt | ||
| Genomic | GenBank:CR352324 (1) | 206894 nt | ||
| Polypeptide | UniProtKB:Q5BLF6 (1) | 147 aa |
No data available
- Han, X., He, W., Liang, D., Liu, X., Zhou, J., de Thé, H., Zhu, J., Yuan, H. (2024) Creg1 Regulates Erythroid Development via TGF-β/Smad2-Klf1 Axis in Zebrafish. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 11(33):e2402804
- Ketharnathan, S., Pokharel, S., Prykhozhij, S.V., Cordeiro-Santanach, A., Ban, K., Dogan, S., Hoang, H.D., Liebman, M.F., Leung, E., Alain, T., Alecu, I., Bennett, S.A.L., Čuperlović-Culf, M., Dror, Y., Berman, J.N. (2024) Loss of Dnajc21 leads to cytopenia and altered nucleotide metabolism in zebrafish. Leukemia. 38(10):2115-2126
- Liu, W., Lin, S., Li, L., Tai, Z., Liu, J.X. (2023) Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance. Cell regeneration (London, England). 12:1010
- Mao, A., Li, Z., Ning, G., Zhou, Z., Wei, C., Li, J., He, X., Wang, Q. (2023) Sclerotome-derived PDGF signaling functions as a niche cue responsible for primitive erythropoiesis. Development (Cambridge, England). 150(22):
- Xie, L., Tao, Y., Shen, Z., Deng, H., Duan, X., Xue, Y., Chen, D., Li, Y. (2023) Congenital asplenia impairs heme-iron recycling during erythropoiesis in zebrafish. Developmental and comparative immunology. 151:105108
- Capon, S.J., Uribe, V., Dominado, N., Ehrlich, O., Smith, K.A. (2022) Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2. Development (Cambridge, England). 149(9):
- Li, L., Chen, M., Liu, W., Tai, P., Liu, X., Liu, J.X. (2022) Zebrafish cox17 modulates primitive erythropoiesis via regulation of mitochondrial metabolism to facilitate hypoxia tolerance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22596
- Wu, M., Chen, Q., Li, J., Xu, Y., Lian, J., Liu, Y., Meng, P., Zhang, Y. (2022) Gfi1aa/Lsd1 Facilitates Hemangioblast Differentiation Into Primitive Erythrocytes by Targeting etv2 and sox7 in Zebrafish. Frontiers in cell and developmental biology. 9:786426
- Bao, B., An, W., Lu, Q., Wang, Y., Lu, Z., Tu, J., Zhang, H., Duan, Y., Yuan, W., Zhu, X., Jia, H. (2021) Sfxn1 is essential for erythrocyte maturation via facilitating hemoglobin production in zebrafish. Biochimica et biophysica acta. Molecular basis of disease. 1867(5):166096
- Facchinello, N., Laquatra, C., Locatello, L., Beffagna, G., Brañas Casas, R., Fornetto, C., Dinarello, A., Martorano, L., Vettori, A., Risato, G., Celeghin, R., Meneghetti, G., Santoro, M.M., Delahodde, A., Vanzi, F., Rasola, A., Dalla Valle, L., Rasotto, M.B., Lodi, T., Baruffini, E., Argenton, F., Tiso, N. (2021) Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish. Cell Death & Disease. 12:100
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