Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-980526-280
Gene Name: distal-less homeobox gene 3b
Gene Symbol: dlx3b
Previous Names: dlx-3, dlx3, id:ibd3531 (1), wu:fb83f11, zgc:91827
Nomenclature History
GENE EXPRESSION
All Expression Data: 183 figures from 122 publications
Directly Submitted Expression Data: 6 figures (36 images) from Thisse et al., 2005 [eu221]
  5 figures (8 images) from Kudoh et al., 2001 [ibd3531]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Days 14-20 (14d-21d, 6.2mm, 10 teeth)
  anguloarticular, anterior neural plate, branchiostegal membrane, branchiostegal ray 1 (all 56) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 3 genotypes
Alleles: b380, sa22023, sa94
Knockdown reagents: MO1-dlx3b, MO2-dlx3b, MO3-dlx3b, MO4-dlx3b, MO5-dlx3b (1)
PHENOTYPE
Data: 2 figures from 2 publications
Observed in: mandibular arch skeleton joint, otic vesicle

Phenotype of Human Orthologue OMIM Phenotype ID
Amelogenesis imperfecta, hypomaturation-hypoplastic type, with taurodontism 104510
Trichodontoosseous syndrome 190320
GENE ONTOLOGY
Ontology GO Term
Biological Process camera-type eye development (more)
Cellular Component nucleus (more)
Molecular Function sequence-specific DNA binding (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000047 (1)
  • InterPro:IPR001356 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • InterPro:IPR020479 (1)
  • InterPro:IPR022135 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • Pfam:PF12413 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA dlx3b-001 (1) 1591
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM dlx3b No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    dlx3b Contained in: [BAC] CH73-209K3 (1) (order this)
    dlx3b Encodes: [EST] eu221 (1), fb83f11, ibd3531 (1) (order this)
    [cDNA] MGC:91827 (1) (order this), MGC:191167 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131322 (1) 1593 bp
    Genomic GenBank:CU468219 (1) 126695 bp
    Select Tool
    Polypeptide UniProtKB:Q01702 (1) 269 aa
    Sequence Clusters UniGene:77568 (1)
    Sequence Information (all 18)
    OTHER dlx3b GENE PAGES
  • Gene:30585 (1)
  • VEGA:OTTDARG00000035619 (1)
  • Ensembl(Zv9):ENSDARG00000014626 (1)
  • MAPPING INFORMATION
    Chr: 12 Details View Map: Merged   Individual Panels
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish dlx3b 12  
    Human DLX3 17 (17q21)
  • OMIM:600525
  • Gene:1747
  • Mouse Dlx3 11 ( 59.01 cM)
  • MGI:94903
  • Gene:13393
  • CITATIONS (250)