Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-980526-280
Gene Name: distal-less homeobox 3b
Gene Symbol: dlx3b
Previous Names: dlx-3, dlx3, id:ibd3531 (1), wu:fb83f11, zgc:91827
Location: Chr: 12   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 192 figures from 127 publications
Directly Submitted Expression Data: 6 figures (36 images) from Thisse et al., 2005 [eu221]
  5 figures (8 images) from Kudoh et al., 2001 [ibd3531]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Days 14-20 (14d-21d, 6.2mm, 10 teeth)
  anguloarticular, anterior neural plate, branchiostegal membrane, branchiostegal ray 1 (all 63) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 5 genotypes
Alleles: b380, sa22023, sa94
Knockdown reagents: MO1-dlx3b, MO2-dlx3b, MO3-dlx3b, MO4-dlx3b, MO5-dlx3b (1)
PHENOTYPE
Data: 2 figures from 2 publications
Observed in: mandibular arch skeleton joint, otic vesicle

Phenotype of Human Orthologue OMIM Phenotype ID
Amelogenesis imperfecta, type IV 104510
Trichodontoosseous syndrome 190320
GENE ONTOLOGY
Ontology GO Term
Biological Process auditory receptor cell fate specification (more)
Cellular Component nucleus (more)
Molecular Function sequence-specific DNA binding (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000047 (1)
  • InterPro:IPR001356 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • InterPro:IPR020479 (1)
  • InterPro:IPR022135 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • Pfam:PF12413 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA dlx3b-001 (1) 1591
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM dlx3b No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    dlx3b Contained in: [BAC] CH73-209K3 (1) (order this)
    dlx3b Encodes: [EST] eu221 (1), fb83f11, ibd3531 (1) (order this)
    [cDNA] MGC:91827 (1) (order this), MGC:191167 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131322 (1) 1593 bp
    Genomic GenBank:CU468219 (1) 126695 bp
    Select Tool
    Polypeptide UniProtKB:Q01702 (1) 269 aa
    Sequence Clusters UniGene:77568 (1)
    Sequence Information (all 18)
    OTHER dlx3b GENE PAGES
  • Gene:30585 (1)
  • VEGA:OTTDARG00000035619 (1)
  • Ensembl(Zv9):ENSDARG00000014626 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish dlx3b 12  
    Human DLX3 17 (17q21)
  • OMIM:600525
  • Gene:1747
  • Mouse Dlx3 11 ( 59.01 cM)
  • MGI:94903
  • Gene:13393
  • Orthology Details
    CITATIONS (251)