Gene

mast1b

ID

ZDB-GENE-131025-2

Name

microtubule associated serine/threonine kinase 1b

Symbol

mast1b Nomenclature History

Previous Names

id:ibd3427

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity. Predicted to be involved in cytoskeleton organization; intracellular signal transduction; and peptidyl-serine phosphorylation. Human ortholog(s) of this gene implicated in mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations. Is expressed in hindbrain; midbrain; spinal cord; telencephalon; and yolk syncytial layer. Orthologous to human MAST1 (microtubule associated serine/threonine kinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from Kudoh et al., 2001

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mast1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations	Alliance	Mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations	618273

Associated With mast1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Domain	IPR000719	Protein kinase domain
Domain	IPR000961	AGC-kinase, C-terminal
Domain	IPR001478	PDZ domain
Domain	IPR015022	Microtubule-associated serine/threonine-protein kinase, pre-PK domain
Domain	IPR037711	Microtubule-associated serine/threonine-protein kinase, catalytic domain
Family	IPR050236	Serine/threonine-protein kinases, AGC
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR023142	Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily

Domain Details Per Protein

Protein	Length	AGC-kinase, C-terminal	Microtubule-associated serine/threonine-protein kinase, catalytic domain	Microtubule-associated serine/threonine-protein kinase, pre-PK domain	Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily	PDZ domain	PDZ superfamily	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site	Serine/threonine-protein kinases, AGC
UniProtKB:A0A8M3AXQ6 InterPro	1634

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mast1b-201 (1) Ensembl	Ensembl	4,776 nt	Select Tool ZFIN BLAST
mRNA	mast1b-202 (1) Ensembl	Ensembl	7,288 nt	Select Tool ZFIN BLAST
mRNA	mast1b-203 (1) Ensembl	Ensembl	2,310 nt	Select Tool ZFIN BLAST
mRNA	mast1b-204 (1) Ensembl	Ensembl	4,722 nt	Select Tool ZFIN BLAST
mRNA	mast1b-205 (1) Ensembl	Ensembl	4,764 nt	Select Tool ZFIN BLAST
mRNA	mast1b-206 (1) Ensembl	Ensembl	1,422 nt	Select Tool ZFIN BLAST
mRNA	mast1b-207 (1) Ensembl	Ensembl	4,581 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations