Gene

hspa8b

ID

ZDB-GENE-121214-31

Name

heat shock protein family A (Hsp70) member 8b

Symbol

hspa8b Nomenclature History

Previous Names

si:dkey-4p15.3

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have several functions, including ATP binding activity; misfolded protein binding activity; and protein folding chaperone. Predicted to be involved in several processes, including cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Predicted to localize to cytosol; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Is expressed in somite. Orthologous to human HSPA8 (heat shock protein family A (Hsp70) member 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hspa8b Human Ortholog

No data available

Associated With hspa8b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018181	Heat shock protein 70, conserved site
Family	IPR013126	Heat shock protein 70 family
Homologous_superfamily	IPR029047	Heat shock protein 70kD, peptide-binding domain superfamily
Homologous_superfamily	IPR029048	Heat shock protein 70kD, C-terminal domain superfamily
Homologous_superfamily	IPR043129	ATPase, nucleotide binding domain

Domain Details Per Protein

Protein	Length	ATPase, nucleotide binding domain	Heat shock protein 70, conserved site	Heat shock protein 70 family	Heat shock protein 70kD, C-terminal domain superfamily	Heat shock protein 70kD, peptide-binding domain superfamily
UniProtKB:F1R9V3 InterPro	647

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	si:dkey-4p15.3-201 (1) Ensembl	Ensembl	2,510 nt	Select Tool
mRNA	si:dkey-4p15.3-202 (1) Ensembl	Ensembl	634 nt	Select Tool
ncRNA	si:dkey-4p15.3-003 (1) Ensembl	Ensembl	734 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations