Gene
tapbpl
- ID
- ZDB-GENE-121003-1
- Name
- TAP binding protein like
- Symbol
- tapbpl Nomenclature History
- Previous Names
-
- tapbpr (1)
- fk53d08
- wu:fk53d08
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable MHC class I protein complex binding activity and TAP complex binding activity. Predicted to be involved in peptide antigen assembly with MHC class I protein complex. Predicted to act upstream of or within antigen processing and presentation of endogenous peptide antigen via MHC class I. Predicted to be located in plasma membrane. Predicted to be part of MHC class I peptide loading complex. Orthologous to human TAPBPL (TAP binding protein like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Gao et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Immune Recognition and Response Modulators | Immunoglobulin C1-set | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin V-set domain | Tapasin |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1QHB2 | InterPro | 462 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tapbpl-201
(1)
|
Ensembl | 963 nt | ||
| mRNA |
tapbpl-202
(1)
|
Ensembl | 4,755 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-234A4 | ||
| Contained in | BAC | CH211-254C9 | ||
| Encodes | EST | fk53d08 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001919950 (1) | 1782 nt | ||
| Genomic | GenBank:CU104697 (1) | 181691 nt | ||
| Polypeptide | UniProtKB:A0A8M1QHB2 (1) | 462 aa |
- Comparative Orthology
- Alliance
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | TAPBPL | 12 | Phylogenetic tree (1) |
- Grimholt, U. (2018) Whole genome duplications have provided teleosts with many roads to peptide loaded MHC class I molecules. BMC Evolutionary Biology. 18:25
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gao, Y., Wu, H., Wang, Q., Qu, J., Liu, Q., Xiao, J., Zhang, Y. (2014) A live attenuated combination vaccine evokes effective immune-mediated protection against Edwardsiella tarda and Vibrio anguillarum. Vaccine. 32(45):5937-44
- Yang, D., Liu, Q., Ni, C., Li, S., Wu, H., Wang, Q., Xiao, J., and Zhang, Y. (2013) Gene expression profiling in live attenuated Edwardsiella tarda vaccine immunized and challenged zebrafish: Insights into the basic mechanisms of protection seen in immunized fish. Developmental and comparative immunology. 40(2):132-41
- Yang, D., Liu, Q., Yang, M., Wu, H., Wang, Q., Xiao, J., and Zhang, Y. (2012) RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish. BMC Genomics. 13(1):319
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