Gene

mgmt

ID
ZDB-GENE-120614-1
Name
O-6-methylguanine-DNA methyltransferase
Symbol
mgmt Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to enable methylated-DNA-[protein]-cysteine S-methyltransferase activity. Predicted to be involved in DNA repair. Predicted to act upstream of or within DNA damage response and methylation. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); granulosa cell tumor; high grade glioma (multiple); and retinoblastoma. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
No data available
Sequence Targeting Reagents
No data available
Human Disease
Associated With mgmt Human Ortholog
No data available
Associated With mgmt Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR001497 Methylated-DNA-[protein]-cysteine S-methyltransferase, active site
Domain IPR008332 Methylguanine DNA methyltransferase, ribonuclease-like domain
Domain IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding
Homologous_superfamily IPR036217 Methylated DNA-protein cysteine methyltransferase, DNA binding domain
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length Methylated DNA-protein cysteine methyltransferase, DNA binding domain Methylated DNA-protein cysteine methyltransferase domain superfamily Methylated-DNA-[protein]-cysteine S-methyltransferase, active site Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding Methylguanine DNA methyltransferase, ribonuclease-like domain Winged helix-like DNA-binding domain superfamily
UniProtKB:X1WB89 InterPro 187
UniProtKB:F1R3V2 InterPro 192
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 17
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA mgmt-201 (1)
Ensembl
Ensembl 1,061 nt
ZFIN BLAST
mRNA mgmt-202 (1)
Ensembl
Ensembl 773 nt
ZFIN BLAST
mRNA mgmt-203 (1)
Ensembl
Ensembl 911 nt
ZFIN BLAST
mRNA mgmt-204 (1)
Ensembl
Ensembl 749 nt
ZFIN BLAST
mRNA mgmt-205 (1)
Ensembl
Ensembl 800 nt
ZFIN BLAST
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-207N2ZFIN Curated Data
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Sequences
Type Accession # Sequence Length (nt/aa) Analysis
RNARefSeq:NM_001256243 (1)1093 nt
ZFIN BLASTNCBI BLASTEnsemblUCSC BLAT
GenomicGenBank:BX005070 (1)242955 nt
MegaBLAST
PolypeptideUniProtKB:F1R3V2 (1)192 aa
ZFIN BLASTSIB BLASTEnsembl Protein Blast
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanMGMT10
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseMgmt7
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
TSV
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