Gene
mgmt
- ID
- ZDB-GENE-120614-1
- Name
- O-6-methylguanine-DNA methyltransferase
- Symbol
- mgmt Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable methylated-DNA-[protein]-cysteine S-methyltransferase activity. Predicted to be involved in DNA repair. Predicted to act upstream of or within cellular response to DNA damage stimulus and methylation. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); granulosa cell tumor; high grade glioma (multiple); and retinoblastoma. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR001497 | Methylated-DNA-[protein]-cysteine S-methyltransferase, active site |
| Domain | IPR008332 | Methylguanine DNA methyltransferase, ribonuclease-like domain |
| Domain | IPR014048 | Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding |
| Homologous_superfamily | IPR036217 | Methylated DNA-protein cysteine methyltransferase, DNA binding domain |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036631 | Methylated DNA-protein cysteine methyltransferase domain superfamily |
Domain Details Per Protein
| Protein | Length | Methylated DNA-protein cysteine methyltransferase, DNA binding domain | Methylated DNA-protein cysteine methyltransferase domain superfamily | Methylated-DNA-[protein]-cysteine S-methyltransferase, active site | Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding | Methylguanine DNA methyltransferase, ribonuclease-like domain | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:X1WB89
|
187 | ||||||
|
UniProtKB:F1R3V2
|
192 |
Interactions and Pathways
No data available
Plasmids
No data available