Gene
selp
- ID
- ZDB-GENE-110107-2
- Name
- selectin P
- Symbol
- selp Nomenclature History
- Previous Names
-
- si:ch211-260g14.4
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable oligosaccharide binding activity and sialic acid binding activity. Acts upstream of or within hematopoietic stem cell migration to bone marrow and hemopoiesis. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in head; trunk; and vascular cord. Human ortholog(s) of this gene implicated in atopic dermatitis and myocardial infarction. Orthologous to human SELP (selectin P).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sun et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Esain et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa3047 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23751 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa39288 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43485 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Complement & Cell Adhesion Regulators | C-type lectin, conserved site | C-type lectin fold | C-type lectin-like | C-type lectin-like/link domain superfamily | EGF-like domain | Selectin, C-type lectin-like domain | Selectin superfamily | Sushi/SCR/CCP domain | Sushi/SCR/CCP superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E5DV48
|
868 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-260G14 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001243323 (1) | 2800 nt | ||
| Genomic | GenBank:BX296562 (1) | 129328 nt | ||
| Polypeptide | UniProtKB:E5DV48 (1) | 868 aa |
- Comparative Orthology
- Alliance
- Boswell, M., Boswell, W., Lu, Y., Savage, M., Walter, R.B. (2020) Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Scientific Reports. 10:3321
- Zheng, Y., Yuan, J., Meng, S., Chen, J., Gu, Z. (2018) Testicular transcriptome alterations in zebrafish (Danio rerio) exposure to 17β-estradiol. Chemosphere. 218:14-25
- Macaulay, I.C., Svensson, V., Labalette, C., Ferreira, L., Hamey, F., Voet, T., Teichmann, S.A., Cvejic, A. (2016) Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells. Cell Reports. 14(4):966-77
- Esain, V., Kwan, W., Carroll, K.J., Cortes, M., Liu, S.Y., Frechette, G.M., Sheward, L.M., Nissim, S., Goessling, W., North, T.E. (2015) Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via PGE2 and P-selectin Activity. Stem cells (Dayton, Ohio). 33(8):2596-612
- Ren, D.L., Sun, A.A., Li, Y.J., Chen, M., Ge, S.C., Hu, B. (2015) Exogenous melatonin inhibits neutrophil migration through suppression of ERK activation. The Journal of endocrinology. 227(1):49-60
- Lam, S.H., Ung, C.Y., Hlaing, M.M., Hu, J., Li, Z.H., Mathavan, S., and Gong, Z. (2013) Molecular insights into 4-nitrophenol-induced hepatotoxicity in zebrafish: Transcriptomic, histological and targeted gene expression analyses. Biochimica et biophysica acta. General subjects. 1830(10):4778-4789
- Sun, G., Pan, J., Liu, K., Wang, X., and Wang, S. (2010) Molecular Cloning and Expression Analysis of P-Selectin from Zebrafish (Danio rerio). International Journal of Molecular Sciences. 11(11):4618-4630
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