Gene

kif1aa

ID

ZDB-GENE-100913-3

Name

kinesin family member 1Aa

Symbol

kif1aa Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have ATP-dependent microtubule motor activity, plus-end-directed and microtubule binding activity. Predicted to be involved in cytoskeleton-dependent intracellular transport; microtubule-based movement; and vesicle-mediated transport. Predicted to localize to axon; dendrite; and microtubule cytoskeleton. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 9; hereditary sensory neuropathy; hereditary sensory neuropathy type 2C; hereditary spastic paraplegia; and hereditary spastic paraplegia 30. Orthologous to human KIF1A (kinesin family member 1A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kif1aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hereditary sensory neuropathy type 2C	Alliance	Neuropathy, hereditary sensory, type IIC	614213
hereditary spastic paraplegia 30	Alliance	Spastic paraplegia 30, autosomal dominant	610357
NESCAV syndrome	Alliance	NESCAV syndrome	614255
		Spastic paraplegia 30, autosomal recessive	620607

Associated With kif1aa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019821	Kinesin motor domain, conserved site
Domain	IPR000253	Forkhead-associated (FHA) domain
Domain	IPR001752	Kinesin motor domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR022140	Kinesin-like KIF1-type
Domain	IPR022164	Kinesin-like
Domain	IPR032405	Kinesin-associated
Domain	IPR049779	Kinesin-like protein KIF1A, forkhead associated domain
Domain	IPR049780	Kinesin-like protein KIF1A/B, pleckstrin homology domain
Homologous_superfamily	IPR008984	SMAD/FHA domain superfamily
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily

Domain Details Per Protein

Protein	Length	Forkhead-associated (FHA) domain	Kinesin-associated	Kinesin-like	Kinesin-like KIF1-type	Kinesin-like protein KIF1A/B, pleckstrin homology domain	Kinesin-like protein KIF1A, forkhead associated domain	Kinesin motor domain	Kinesin motor domain, conserved site	Kinesin motor domain superfamily	PH-like domain superfamily	Pleckstrin homology domain	P-loop containing nucleoside triphosphate hydrolase	SMAD/FHA domain superfamily
UniProtKB:A0A8M9QB03 InterPro	1790
UniProtKB:A0A8M9Q6U1 InterPro	1889
UniProtKB:A0A8M9PMT7 InterPro	1875
UniProtKB:A0A8M9Q6U5 InterPro	1817
UniProtKB:A0A8M3B0H2 InterPro	1782
UniProtKB:A0A8M9QG12 InterPro	1898
UniProtKB:A0A8M9PMT3 InterPro	1891
UniProtKB:A0A8M2BDC9 InterPro	1809
UniProtKB:A0A8M9PMU1 InterPro	1717
UniProtKB:A0A8M9Q0I0 InterPro	1862
UniProtKB:A0A8M9QAZ5 InterPro	1897
UniProtKB:A0A8M2BDA1 InterPro	1825
UniProtKB:A0A8M9QG16 InterPro	1885
UniProtKB:A0A8M2BDA4 InterPro	1708
UniProtKB:A0A8M9Q0H6 InterPro	1889
UniProtKB:X1WHC0 InterPro	1681
UniProtKB:A0A8M1RDJ7 InterPro	1672
UniProtKB:A0A8M2BDH2 InterPro	1680
UniProtKB:A0A8M9QG21 InterPro	1797

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	kif1aa-201 (1) Ensembl	Ensembl		5,037 nt	Select Tool ZFIN BLAST
mRNA	kif1aa-202 (1) Ensembl	Ensembl		9,247 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations