Gene
zbtb4
- ID
- ZDB-GENE-100318-5
- Name
- zinc finger and BTB domain containing 4
- Symbol
- zbtb4 Nomenclature History
- Previous Names
-
- kzp (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Acts upstream of or within convergent extension involved in gastrulation; regionalization; and regulation of DNA-templated transcription. Located in nucleus. Is expressed in eye; forebrain; head; and midbrain hindbrain boundary. Orthologous to human ZBTB4 (zinc finger and BTB domain containing 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Yao et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1477 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12483 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12821 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17032 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22094 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35288 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35289 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44762 | Allele with one point mutation | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-zbtb4 | N/A | (3) |
| MO2-zbtb4 | N/A | Yao et al., 2010 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type | Zinc finger protein, C2H2-type |
|---|---|---|---|---|
|
UniProtKB:A0A0R4INF0
|
1570 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-222B21 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-38P12 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001339110 (1) | 8926 nt | ||
| Genomic | GenBank:AL929346 (1) | 184825 nt | ||
| Polypeptide | UniProtKB:A0A0R4INF0 (1) | 1570 aa |
- Kok, F.O., Shin, M., Ni, C., Gupta, A., Grosse, A.S., van Impel, A., Kirchmaier, B.C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S.A., Lawson, N.D. (2015) Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Developmental Cell. 32(1):97-108
- Liu, F., Yao, S., Zhang, T., Xiao, C., Shang, Y., Liu, J., and Mo, X. (2012) Kzp Regulates the Transcription of gata2 and pu.1 During Primitive Hematopoiesis in Zebrafish Embryos. Journal of genetics and genomics = Yi chuan xue bao. 39(9):463-471
- Narayanan, A., and Lekven, A.C. (2012) Biphasic wnt8a expression is achieved through interactions of multiple regulatory inputs. Developmental Dynamics : an official publication of the American Association of Anatomists. 241(6):1062-1075
- Yao, S., Qian, M., Deng, S., Xie, L., Yang, H., Xiao, C., Zhang, T., Xu, H., Zhao, X., Wei, Y.Q., and Mo, X. (2010) KZP controls canonical WNT8 signaling to modulate dorsoventral patterning during zebrafish gastrulation. The Journal of biological chemistry. 285(53):42086-42096
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