Gene
vwa2
- ID
- ZDB-GENE-100302-1
- Name
- von Willebrand factor A domain containing 2
- Symbol
- vwa2 Nomenclature History
- Previous Names
-
- AMACO (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within epithelial structure maintenance. Predicted to be active in basement membrane and extracellular space. Is expressed in several structures, including fin; median fin fold; myoseptum; nervous system; and somite. Orthologous to human VWA2 (von Willebrand factor A domain containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa15844 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18645 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22126 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22127 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-vwa2 | N/A | Richardson et al., 2014 |
| MO2-vwa2 | N/A | Richardson et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR002035 | von Willebrand factor, type A |
| Family | IPR050525 | Extracellular Matrix Assembly and Organization |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR036465 | von Willebrand factor A-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like calcium-binding domain | EGF-like domain | Extracellular Matrix Assembly and Organization | Growth factor receptor cysteine-rich domain superfamily | von Willebrand factor A-like domain superfamily | von Willebrand factor, type A |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:U3JA51 | InterPro | 795 | ||||||
| UniProtKB:A0A8M9Q0S3 | InterPro | 795 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-225B10 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-84E12 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_690723 (1) | 4100 nt | ||
| Genomic | GenBank:BX465198 (1) | 194152 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q0S3 (1) | 795 aa |
- Doretto, L.B., Butzge, A.J., Nakajima, R.T., Martinez, E.R.M., de Souza, B.M., Rodrigues, M.D.S., Rosa, I.F., Ricci, J.M.B., Tovo-Neto, A., Costa, D.F., Malafaia, G., Shao, C., Nóbrega, R.H. (2022) Gdnf Acts as a Germ Cell-Derived Growth Factor and Regulates the Zebrafish Germ Stem Cell Niche in Autocrine- and Paracrine-Dependent Manners. Cells. 11(8):
- Zhao, J., Wang, B., Yu, H., Wang, Y., Liu, X., Zhang, Q. (2018) tdrd1 is a germline-specific and sexually dimorphically expressed gene in Paralichthys olivaceus. Gene. 673:61-69
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Richardson, R.J., Gebauer, J.M., Zhang, J.L., Kobbe, B., Keene, D.R., Karlsen, K.R., Richetti, S., Wohl, A.P., Sengle, G., Neiss, W.F., Paulsson, M., Hammerschmidt, M., and Wagener, R. (2014) AMACO Is a Component of the Basement Membrane-Associated Fraser Complex. The Journal of investigative dermatology. 134(5):1313-22
- Gebauer, J.M., Karlsen, K.R., Neiss, W.F., Paulsson, M., and Wagener, R. (2010) Expression of the AMACO (VWA2 protein) ortholog in zebrafish. Gene expression patterns : GEP. 10(1):53-59
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