ZFIN is now using GRCz12tu for Genomic Data
Gene
slc4a4b
- ID
- ZDB-GENE-091030-1
- Name
- solute carrier family 4 member 4b
- Symbol
- slc4a4b Nomenclature History
- Previous Names
-
- nbce1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable sodium:bicarbonate symporter activity. Predicted to be involved in bicarbonate transport; regulation of intracellular pH; and transmembrane transport. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including NCC ionocyte; ball; gill; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in proximal renal tubular acidosis-ocular anomaly syndrome and renal tubular acidosis. Orthologous to human SLC4A4 (solute carrier family 4 member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| proximal renal tubular acidosis-ocular anomaly syndrome | Alliance | Proximal renal tubular acidosis-ocular anomaly syndrome | 604278 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011531 | Bicarbonate transporter-like, transmembrane domain |
| Domain | IPR013769 | Band 3 cytoplasmic domain |
| Family | IPR003020 | Bicarbonate transporter, eukaryotic |
| Family | IPR003024 | Sodium bicarbonate cotransporter |
| Homologous_superfamily | IPR016152 | Phosphotransferase/anion transporter |
Domain Details Per Protein
| Protein | Additional Resources | Length | Band 3 cytoplasmic domain | Bicarbonate transporter, eukaryotic | Bicarbonate transporter-like, transmembrane domain | Phosphotransferase/anion transporter | Sodium bicarbonate cotransporter |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q313 | InterPro | 918 | |||||
| UniProtKB:A0A8N7UV75 | InterPro | 1073 | |||||
| UniProtKB:A0A8M3B4G9 | InterPro | 1105 | |||||
| UniProtKB:A0A8M3AL80 | InterPro | 1122 | |||||
| UniProtKB:F1QD14 | InterPro | 1090 | |||||
| UniProtKB:A0AB32TF60 | InterPro | 904 | |||||
| UniProtKB:A0AB32TLY6 | InterPro | 856 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc4a4b-201
(1)
|
Ensembl | 3,571 nt | ||
| mRNA |
slc4a4b-202
(1)
|
Ensembl | 3,342 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers