Gene
tnfsf11
- ID
- ZDB-GENE-090805-2
- Name
- TNF superfamily member 11
- Symbol
- tnfsf11 Nomenclature History
- Previous Names
-
- RANKL (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Acts upstream of or within response to mechanical stimulus. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in head and scale. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF superfamily member 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa38731 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive osteopetrosis 2 | Alliance | Osteopetrosis, autosomal recessive 2 | 259710 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Tumour necrosis factor domain | Tumour necrosis factor-like domain superfamily |
|---|---|---|---|
|
UniProtKB:E7F3U1
|
251 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnfsf11-201
(1)
|
Ensembl | 1,548 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-tnfsf11 | polyclonal | IgG | Rabbit |
|
Abcam plc
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-178E6 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_002663351 (1) | 4066 nt | ||
| Genomic | GenBank:FP016125 (1) | 103404 nt | ||
| Polypeptide | UniProtKB:E7F3U1 (1) | 251 aa |
- Jiang, R.X., Hu, N., Deng, Y.W., Hu, L.W., Gu, H., Luo, N., Wen, J., Jiang, X.Q. (2024) Potential therapeutic role of spermine via Rac1 in osteoporosis: Insights from zebrafish and mice. Zoological research. 45:367380367-380
- Yu, T., Chen, M., Wen, J., Liu, J., Li, K., Jin, L., Yue, J., Yang, Z., Xi, J. (2024) The effects of all-trans retinoic acid on prednisolone-induced osteoporosis in zebrafish larvae. Bone. 189:117261
- Daponte, V., Tonelli, F., Masiero, C., Syx, D., Exbrayat-Héritier, C., Biggiogera, M., Willaert, A., Rossi, A., Coucke, P.J., Ruggiero, F., Forlino, A. (2023) Cell differentiation and matrix organization are differentially affected during bone formation in osteogenesis imperfecta zebrafish models with different genetic defects impacting collagen type I structure. Matrix biology : journal of the International Society for Matrix Biology. 121:105-126
- Guo, W., Jin, P., Li, R., Huang, L., Liu, Z., Li, H., Zhou, T., Fang, B., Xia, L. (2023) Dynamic network biomarker identifies cdkn1a-mediated bone mineralization in the triggering phase of osteoporosis. Experimental & molecular medicine. 55(1):81-94
- Seda, M., Crespo, B., Corcelli, M., Osborn, D.P., Jenkins, D. (2023) A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosis. Scientific Reports. 13:67836783
- Zhong, Y.T., Liao, H.B., Ye, Z.Q., Jiang, H.S., Li, J.X., Ke, L.M., Hua, J.Y., Wei, B., Wu, X., Cui, L. (2023) Eurycomanone stimulates bone mineralization in zebrafish larvae and promotes osteogenic differentiation of mesenchymal stem cells by upregulating AKT/GSK-3β/β-catenin signaling. Journal of orthopaedic translation. 40:132146132-146
- Cao, M., Wang, N., Yan, X., Yang, N., Fu, Q., Zhang, X., Zhang, Y., Li, C. (2022) Structures, evolutionary relationships and expression profiles of the tumour necrosis factor superfamily and their receptors in black rockfish (Sebastes schlegelii). Developmental and comparative immunology. 132:104405
- Peng, C.H., Lin, W.Y., Li, C.Y., Dharini, K.K., Chang, C.Y., Hong, J.T., Lin, M.D. (2022) Gu Sui Bu (Drynaria fortunei J. Sm.) antagonizes glucocorticoid-induced mineralization reduction in zebrafish larvae by modulating the activity of osteoblasts and osteoclasts. Journal of ethnopharmacology. 297:115565
- Wang, F., Rong, P., Wang, J., Yu, X., Wang, N., Wang, S., Xue, Z., Chen, J., Meng, W., Peng, X. (2022) Anti-osteoporosis effects and regulatory mechanism of Lindera aggregata based on network pharmacology and experimental validation. Food & function. 13(11):6419-6432
- Xu, P., Lin, B., Deng, X., He, S., Chen, N., Wang, N. (2022) Anti-osteoporosis effects of Anemarrhenae Rhizoma / Phellodendri Chinensis Cortex herb pair and its major active components in diabetic rats and zebrafish. Journal of ethnopharmacology. 293:115269
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