ZFIN is now using GRCz12tu for Genomic Data
Gene
dync1i2b
- ID
- ZDB-GENE-090121-1
- Name
- dynein, cytoplasmic 1, intermediate chain 2b
- Symbol
- dync1i2b Nomenclature History
- Previous Names
-
- fk28d02
- wu:fk28d02
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in transport along microtubule. Predicted to act upstream of or within microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Is expressed in female organism. Orthologous to human DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dync1i2b | Ansar et al., 2019 | |
| CRISPR2-dync1i2b | Ansar et al., 2019 | |
| MO1-dync1i2b | N/A | Ansar et al., 2019 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with microcephaly and structural brain anomalies | 618492 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR025956 | Cytoplasmic dynein 1 intermediate chain 1/2 |
| Family | IPR050687 | Dynein Intermediate Chain |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cytoplasmic dynein 1 intermediate chain 1/2 | Dynein Intermediate Chain | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IXD8 | InterPro | 628 | |||||
| UniProtKB:A0A8M3B334 | InterPro | 645 | |||||
| UniProtKB:A0A8M3AT17 | InterPro | 625 | |||||
| UniProtKB:A0A8M3BA49 | InterPro | 608 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dync1i2b-201
(1)
|
Ensembl | 1,887 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
No data available
- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009302110 (1) | GRCz12tu | 3268 nt | |
| Genomic | GenBank:CR384078 (1) | 158424 nt | ||
| Polypeptide | UniProtKB:A0A8M3B334 (1) | 645 aa |
- Freeburg, S.H., Shwartz, A., Kemény, L.V., Smith, C.J., Weeks, O., Miller, B.M., PenkoffLidbeck, N., Fisher, D.E., Evason, K.J., Goessling, W. (2024) Hepatocyte vitamin D receptor functions as a nutrient sensor that regulates energy storage and tissue growth in zebrafish. Cell Reports. 43:114393114393
- Ansar, M., Ullah, F., Paracha, S.A., Adams, D.J., Lai, A., Pais, L., Iwaszkiewicz, J., Millan, F., Sarwar, M.T., Agha, Z., Shah, S.F., Qaisar, A.A., Falconnet, E., Zoete, V., Ranza, E., Makrythanasis, P., Santoni, F.A., Ahmed, J., Katsanis, N., Walsh, C., Davis, E.E., Antonarakis, S.E. (2019) Bi-allelic Variants in DYNC1I2 Cause Syndromic Microcephaly with Intellectual Disability, Cerebral Malformations, and Dysmorphic Facial Features. American journal of human genetics. 104(6):1073-1087
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Gebauer, J.M., Kobbe, B., Paulsson, M., Wagener, R. (2016) Structure, evolution and expression of collagen XXVIII: Lessons from the zebrafish. Matrix biology : journal of the International Society for Matrix Biology. 49:106-19
- See, K., Yadav, P., Giegerich, M., Cheong, P.S., Graf, M., Vyas, H., Lee, S.G., Mathavan, S., Fischer, U., Sendtner, M., and Winkler, C. (2014) SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy. Human molecular genetics. 23(7):1754-70
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