Gene
ifih1
- ID
- ZDB-GENE-081104-438
- Name
- interferon induced with helicase C domain 1
- Symbol
- ifih1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Exhibits protein heterodimerization activity. Involved in regulation of transcription, DNA-templated. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human IFIH1 (interferon induced with helicase C domain 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Aicardi-Goutieres syndrome | Alliance | Aicardi-Goutieres syndrome 7 | 615846 |
| Immunodeficiency 95 | 619773 | ||
| Singleton-Merten syndrome 1 | 182250 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR006935 | Helicase/UvrB, N-terminal |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR021673 | RIG-I-like receptor, C-terminal regulatory domain |
| Domain | IPR031964 | Caspase recruitment domain |
| Domain | IPR041204 | RIG-I-like receptor, C-terminal |
| Family | IPR051363 | RIG-I-like Receptor (RLR) Helicase |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR038557 | RIG-I-like receptor, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Caspase recruitment domain | Death-like domain superfamily | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | Helicase/UvrB, N-terminal | P-loop containing nucleoside triphosphate hydrolase | RIG-I-like receptor, C-terminal | RIG-I-like receptor, C-terminal domain superfamily | RIG-I-like receptor, C-terminal regulatory domain | RIG-I-like Receptor (RLR) Helicase |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0E3D804
|
997 |
Interactions and Pathways
No data available
Plasmids
No data available