Gene

trpc6b

ID

ZDB-GENE-081030-19

Name

transient receptor potential cation channel, subfamily C, member 6b

Symbol

trpc6b Nomenclature History

Previous Names

si:dkey-20h16.3

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in metal ion transport; regulation of cytosolic calcium ion concentration; and single fertilization. Predicted to localize to cation channel complex and integral component of plasma membrane. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 2; and nephrotic syndrome type 2. Is expressed in trigeminal motor nucleus. Orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from von Niederhäusern et al., 2013

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With trpc6b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
focal segmental glomerulosclerosis 2	Alliance	Glomerulosclerosis, focal segmental, 2	603965

Associated With trpc6b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005821	Ion transport domain
Domain	IPR013555	Transient receptor ion channel domain
Family	IPR002153	Transient receptor potential channel, canonical
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	Ion transport domain	Transient receptor ion channel domain	Transient receptor potential channel, canonical
UniProtKB:A0A8M1RKV1 InterPro	858

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	trpc6b-201 (1) Ensembl	Ensembl		2,923 nt	Select Tool
mRNA	trpc6b-202 (1) Ensembl	Ensembl		2,118 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations