Gene
slitrk2
- ID
- ZDB-GENE-080327-7
- Name
- SLIT and NTRK-like family, member 2
- Symbol
- slitrk2 Nomenclature History
- Previous Names
-
- sc:d0319 (1)
- wu:fj38g04
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Acts upstream of or within glial cell development and retina development in camera-type eye. Predicted to be located in membrane. Predicted to be active in glutamatergic synapse. Is expressed in central nervous system; neuroepithelial cell; and retinal neural layer. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual developmental disorder 111. Orthologous to human SLITRK2 (SLIT and NTRK like family member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d0319 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Charlton-Perkins et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-slitrk2 | Charlton-Perkins et al., 2019 | |
CRISPR2-slitrk2 | Charlton-Perkins et al., 2019 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
non-syndromic X-linked intellectual developmental disorder 111 | Alliance | Intellectual developmental disorder, X-linked 111 | 301107 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000372 | Leucine-rich repeat N-terminal domain |
Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
Repeat | IPR001611 | Leucine-rich repeat |
Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
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Domain Details Per Protein
Protein | Additional Resources | Length | Cysteine-rich flanking region, C-terminal | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat N-terminal domain | Leucine-rich repeat, typical subtype |
---|---|---|---|---|---|---|---|
UniProtKB:F1QE14 | InterPro | 854 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
slitrk2-201
(1)
|
Ensembl | 3,032 nt | ||
mRNA |
slitrk2-202
(1)
|
Ensembl | 2,547 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-184I23 | ZFIN Curated Data | |
Encodes | EST | cssl:d0319 | Thisse et al., 2008 | |
Encodes | EST | fj38g04 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_001332731 (1) | 3573 nt | ||
Genomic | GenBank:CR762422 (2) | 151177 nt | ||
Polypeptide | UniProtKB:F1QE14 (1) | 854 aa |
- Lüffe, T.M., D'Orazio, A., Bauer, M., Gioga, Z., Schoeffler, V., Lesch, K.P., Romanos, M., Drepper, C., Lillesaar, C. (2021) Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish-implications for neurodevelopmental disorders. Translational psychiatry. 11:529
- Charlton-Perkins, M., Almeida, A.D., MacDonald, R.B., Harris, W.A. (2019) Genetic control of cellular morphogenesis in Müller glia. Glia. 67(7):1401-1411
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Panza, P., Sitko, A.A., Maischein, H.M., Koch, I., Flötenmeyer, M., Wright, G.J., Mandai, K., Mason, C.A., Söllner, C. (2015) The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm. Neural Development. 10:23
- Round, J., Ross, B., Angel, M., Shields, K., and Lom, B. (2014) Slitrk gene duplication and expression in the developing zebrafish nervous system. Developmental Dynamics : an official publication of the American Association of Anatomists. 243(2):339-49
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