Gene

itga8

ID

ZDB-GENE-080220-48

Name

integrin, alpha 8

Symbol

itga8 Nomenclature History

Previous Names

zgc:172265

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Involved in cilium assembly and embryonic viscerocranium morphogenesis. Predicted to localize to integrin complex. Human ortholog(s) of this gene implicated in end stage renal failure; ovarian cancer; renal agenesis; and schizophrenia. Is expressed in hair cell; head; inner ear; neuromast hair cell; and pharyngeal arch. Orthologous to human ITGA8 (integrin subunit alpha 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With itga8 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
renal agenesis	Alliance	Renal hypodysplasia/aplasia 1	191830

Associated With itga8 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Domain	IPR013649	Integrin alpha, first immunoglubulin-like domain
Domain	IPR048285	Integrin alpha, second immunoglobulin-like domain
Domain	IPR048286	Integrin alpha, third immunoglobulin-like domain
Family	IPR000413	Integrin alpha chain
Homologous_superfamily	IPR028994	Integrin alpha, N-terminal
Homologous_superfamily	IPR032695	Integrin domain superfamily
Repeat	IPR013517	FG-GAP repeat
Repeat	IPR013519	Integrin alpha beta-propellor