Gene

hdc

ID

ZDB-GENE-080102-5

Name

histidine decarboxylase

Symbol

hdc Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have carboxy-lyase activity and pyridoxal phosphate binding activity. Involved in chemical synaptic transmission; nervous system development; and response to light stimulus. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; asthma; and rhinitis. Is expressed in brain; caudal hypothalamic zone; hypothalamus; and posterior recess. Orthologous to human HDC (histidine decarboxylase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

19 figures from 17 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hdc Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Gilles de la Tourette syndrome	Alliance	{Gilles de la Tourette syndrome, susceptibility to}	137580

Associated With hdc Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR021115	Pyridoxal-phosphate binding site
Family	IPR002129	Pyridoxal phosphate-dependent decarboxylase
Family	IPR010977	Aromatic-L-amino-acid decarboxylase
Homologous_superfamily	IPR015421	Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily	IPR015422	Pyridoxal phosphate-dependent transferase, small domain
Homologous_superfamily	IPR015424	Pyridoxal phosphate-dependent transferase