Gene

hdc

ID
ZDB-GENE-080102-5
Name
histidine decarboxylase
Symbol
hdc Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have histidine decarboxylase activity. Involved in chemical synaptic transmission; nervous system development; and response to light stimulus. Predicted to localize to cytoplasm. Is expressed in brain; caudal hypothalamic zone; hypothalamus; and posterior recess. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; asthma; and rhinitis. Orthologous to human HDC (histidine decarboxylase).
Genome Resources
Note
None
Expression
All Expression Data
12 figures from 11 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hdc Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Gilles de la Tourette syndrome Alliance {Gilles de la Tourette syndrome, susceptibility to} 137580
Associated With hdc Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR021115 Pyridoxal-phosphate binding site
Family IPR002129 Pyridoxal phosphate-dependent decarboxylase
Family IPR010977 Aromatic-L-amino-acid decarboxylase
Homologous_superfamily IPR015421 Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily IPR015422 Pyridoxal phosphate-dependent transferase domain 1
Homologous_superfamily IPR015424 Pyridoxal phosphate-dependent transferase
Domain Details Per Protein
Protein Length Aromatic-L-amino-acid decarboxylase Pyridoxal-phosphate binding site Pyridoxal phosphate-dependent decarboxylase Pyridoxal phosphate-dependent transferase Pyridoxal phosphate-dependent transferase domain 1 Pyridoxal phosphate-dependent transferase, major domain
UniProtKB:F8W271 484
UniProtKB:F8W5Y8 594
UniProtKB:A7KBS5 594
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-histamine polyclonal Rabbit
  • IHC
Millipore
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations