Gene

toe1

ID

ZDB-GENE-070912-533

Name

target of EGR1, exonuclease

Symbol

toe1 Nomenclature History

Previous Names

si:dkey-40i22.3

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have 3'-5'-exoribonuclease activity and snRNA binding activity. Involved in brain development and neuron cellular homeostasis. Predicted to localize to Cajal body and cytoplasm. Used to study pontocerebellar hypoplasia. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 7. Orthologous to human TOE1 (target of EGR1, exonuclease).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Diotel et al., 2015

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Lardelli et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With toe1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
pontocerebellar hypoplasia type 7	Alliance	Pontocerebellar hypoplasia, type 7	614969

Associated With toe1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
pontocerebellar hypoplasia	AB/TU + MO2-toe1	standard conditions	Lardelli et al., 2017
pontocerebellar hypoplasia	AB/TU + MO1-toe1	standard conditions	Lardelli et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000571	Zinc finger, CCCH-type
Family	IPR006941	Ribonuclease CAF1
Family	IPR051181	CAF1 family poly(A)-specific ribonucleases
Homologous_superfamily	IPR012337	Ribonuclease H-like superfamily
Homologous_superfamily	IPR036397	Ribonuclease H superfamily
Homologous_superfamily	IPR036855	Zinc finger, CCCH-type superfamily