Gene
hbl1
- ID
- ZDB-GENE-070912-285
- Name
- hexose-binding lectin 1
- Symbol
- hbl1 Nomenclature History
- Previous Names
-
- mbl (1)
- si:ch211-284o19.2
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to be located in membrane. Predicted to be part of collagen trimer. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bacterial infectious disease (multiple); fungal infectious disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human MBL2 (mannose binding lectin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018378 | C-type lectin, conserved site |
| Domain | IPR001304 | C-type lectin-like |
| Family | IPR050801 | Calcium-Dependent Lectins in Immunity and Development |
| Homologous_superfamily | IPR016186 | C-type lectin-like/link domain superfamily |
| Homologous_superfamily | IPR016187 | C-type lectin fold |
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Domain Details Per Protein
| Protein | Length | Calcium-Dependent Lectins in Immunity and Development | Collagen triple helix repeat | C-type lectin, conserved site | C-type lectin fold | C-type lectin-like | C-type lectin-like/link domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AQC7
|
297 | ||||||
|
UniProtKB:A0A8M9PXC5
|
296 | ||||||
|
UniProtKB:E9QHK9
|
254 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-284O19 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068218032 (1) | 1748 nt | ||
| Genomic | GenBank:AL954692 (1) | 101677 nt | ||
| Polypeptide | UniProtKB:A0A8M3AQC7 (1) | 297 aa |
No data available
- Wu, X.M., Cao, L., Hu, Y.W., Chang, M.X. (2019) Transcriptomic characterization of adult zebrafish infected with Streptococcus agalactiae. Fish & shellfish immunology. 94:355-372
- Garcia-Reyero, N., Escalon, L., Prats, E., Faria, M., Soares, A.M., Raldúa, D. (2016) Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes. Bulletin of environmental contamination and toxicology. 96(6):707-713
- Zhang, H., Peatman, E., Liu, H., Niu, D., Feng, T., Kucuktas, H., Waldbieser, G., Chen, L., and Liu, Z. (2012) Characterization of a mannose-binding lectin from channel catfish (Ictalurus punctatus). Research in Veterinary Science. 92(3):408-413
- Jackson, A.N., McLure, C.A., Dawkins, R.L., and Keating, P.J. (2007) Mannose binding lectin (MBL) copy number polymorphism in Zebrafish (D. rerio) and identification of haplotypes resistant to L. anguillarum. Immunogenetics. 59(11):861-872
- Nakao, M., Kajiya, T., Sato, Y., Somamoto, T., Kato-Unoki, Y., Matsushita, M., Nakata, M., Fujita, T., and Yano, T. (2006) Lectin Pathway of Bony Fish Complement: Identification of Two Homologs of the Mannose-Binding Lectin Associated with MASP2 in the Common Carp (Cyprinus carpio). Journal of immunology (Baltimore, Md. : 1950). 177(8):5471-5479
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