Gene
dnah7
- ID
- ZDB-GENE-070912-282
- Name
- dynein, axonemal, heavy chain 7
- Symbol
- dnah7 Nomenclature History
- Previous Names
-
- si:ch211-284h20.3
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and dynein intermediate chain binding activity. Acts upstream of or within determination of liver left/right asymmetry. Predicted to be located in axoneme and microtubule. Predicted to be part of dynein complex. Is expressed in Kupffer's vesicle. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human DNAH7 (dynein axonemal heavy chain 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sampaio et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Sampaio et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1268 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa1875 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa2518 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa7185 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa8404 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa8862 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa10194 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11115 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21492 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27405 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dnah7 | Keatinge et al., 2021 | |
| CRISPR2-dnah7 | Keatinge et al., 2021 | |
| CRISPR3-dnah7 | Wang et al., 2021 | |
| CRISPR4-dnah7 | Wang et al., 2021 | |
| CRISPR5-dnah7 | Wang et al., 2021 | |
| CRISPR6-dnah7 | Wang et al., 2021 | |
| MO1-dnah7 | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ciliary dyskinesia, primary, 50 | 620356 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | Dynein heavy chain | Dynein heavy chain 3, AAA+ lid domain | Dynein heavy chain, AAA1 domain, small subdomain | Dynein heavy chain, AAA 5 extension domain | Dynein heavy chain AAA lid domain | Dynein heavy chain AAA lid domain superfamily | Dynein heavy chain, AAA module D4 | Dynein heavy chain, ATP-binding dynein motor region | Dynein heavy chain, coiled coil stalk | Dynein heavy chain, C-terminal domain | Dynein heavy chain, C-terminal domain, barrel region | Dynein heavy chain, domain 2, N-terminal | Dynein heavy chain, hydrolytic ATP-binding dynein motor region | Dynein heavy chain, linker | Dynein heavy chain, linker, subdomain 3 | Dynein heavy chain region D6 P-loop domain | EF-Hand 1, calcium-binding site | EF-hand domain | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7UQZ5
|
4005 | ||||||||||||||||||||
|
UniProtKB:A0A8M3AW24
|
3927 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-260B17 | ZFIN Curated Data | |
| Contained in | BAC | CH211-284H20 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-187E3 | ZFIN Curated Data | |
| Encodes | EST | wz12356 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_685051 (1) | 15193 nt | ||
| Genomic | GenBank:BX323457 (1) | 172918 nt | ||
| Polypeptide | UniProtKB:A0A8N7UQZ5 (1) | 4005 aa |
- Jacinto, R., Sampaio, P., Roxo-Rosa, M., Pestana, S., Lopes, S.S. (2021) Pkd2 Affects Cilia Length and Impacts LR Flow Dynamics and Dand5. Frontiers in cell and developmental biology. 9:624531
- Keatinge, M., Tsarouchas, T.M., Munir, T., Porter, N.J., Larraz, J., Gianni, D., Tsai, H.H., Becker, C.G., Lyons, D.A., Becker, T. (2021) CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. PLoS Genetics. 17:e1009515
- Wang, Y., Troutwine, B.R., Zhang, H., Gray, R.S. (2021) The axonemal dynein heavy chain 10 gene is essential for monocilia motility and spine alignment in zebrafish. Developmental Biology. 482:82-90
- Zhang, Y., Wang, Y., Yao, X., Wang, C., Chen, F., Liu, D., Shao, M., Xu, Z. (2020) Rbm24a Is Necessary for Hair Cell Development Through Regulating mRNA Stability in Zebrafish. Frontiers in cell and developmental biology. 8:604026
- Tavares, B., Jacinto, R., Sampaio, P., Pestana, S., Pinto, A., Vaz, A., Roxo-Rosa, M., Gardner, R., Lopes, T., Schilling, B., Henry, I., Saúde, L., Lopes, S.S. (2017) Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Foxj1a in zebrafish left-right organizer.. eLIFE. 6
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Martins, R., Vieira, F.A., Power, D.M. (2014) Calcitonin receptor family evolution and fishing for function using in silico promoter analysis. General and comparative endocrinology. 209:61-73
- Sampaio, P., Ferreira, R.R., Guerrero, A., Pintado, P., Tavares, B., Amaro, J., Smith, A.A., Montenegro-Johnson, T., Smith, D.J., Lopes, S.S. (2014) Left-Right Organizer Flow Dynamics: How Much Cilia Activity Reliably Yields Laterality?. Developmental Cell. 29(6):716-28
- Geisler, R., Rauch, G.J., Baier, H., van Bebber, F., Brobeta, L., Dekens, M.P., Finger, K., Fricke, C., Gates, M.A., Geiger, H., Geiger-Rudolph, S., Gilmour, D., Glaser, S., Gnugge, L., Habeck, H., Hingst, K., Holley, S., Keenan, J., Kirn, A., Knaut, H., Lashkari, D., Maderspacher, F., Martyn, U., Neuhauss, S., Neumann, C., Nicolson, T., Pelegri, F., Ray, R., Rick, J.M., Roehl, H., Roeser, T., Schauerte, H.E., Schier, A.F., Schönberger, U., Schönthaler, H.-B., Schulte-Merker, S., Seydler, C., Talbot, W.S., Weiler, C., Nüsslein-Volhard, C., and Haffter, P. (1999) A radiation hybrid map of the zebrafish genome. Nature Genetics. 23(1):86-89
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