Gene
arhgef11
- ID
- ZDB-GENE-070604-1
- Name
- Rho guanine nucleotide exchange factor (GEF) 11
- Symbol
- arhgef11 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables G-protein alpha-subunit binding activity. Acts upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; otolith development; and stress fiber assembly. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in central nervous system; head; and pronephric duct. Orthologous to human ARHGEF11 (Rho guanine nucleotide exchange factor 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Panizzi et al., 2007
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Panizzi et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-arhgef11 | N/A | Panizzi et al., 2007 |
| MO2-arhgef11 | N/A | Panizzi et al., 2007 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001331 | Guanine-nucleotide dissociation stimulator, CDC24, conserved site |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR015212 | Regulator of G protein signalling-like domain |
| Domain | IPR037889 | Rho guanine nucleotide exchange factor 11, RGS domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ARHGEF1-like, PH domain | Dbl homology (DH) domain superfamily | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | PDZ domain | PDZ superfamily | PH-like domain superfamily | Pleckstrin homology domain | Regulator of G protein signalling-like domain | RGS domain superfamily | RGS, subdomain 2 | Rho guanine nucleotide exchange factor 11, RGS domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q49U75 | InterPro | 1417 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arhgef11-201
(1)
|
Ensembl | 2,252 nt | ||
| mRNA |
arhgef11-202
(1)
|
Ensembl | 521 nt | ||
| mRNA |
arhgef11-203
(1)
|
Ensembl | 5,755 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-67A8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195123 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001031840 (1) | 4254 nt | ||
| Genomic | GenBank:BX323566 (1) | 108226 nt | ||
| Polypeptide | UniProtKB:Q49U75 (1) | 1417 aa |
- Caetano da Silva, C., Macias Trevino, C., Mitchell, J., Murali, H., Tsimbal, C., Dalessandro, E., Carroll, S.H., Kochhar, S., Curtis, S.W., Cheng, C.H.E., Wang, F., Kutschera, E., Carstens, R.P., Xing, Y., Wang, K., Leslie, E.J., Liao, E.C. (2024) Functional analysis of ESRP1/2 gene variants and CTNND1 isoforms in orofacial cleft pathogenesis. Communications biology. 7:10401040
- Qian, W., Yamaguchi, N., Lis, P., Cammer, M., Knaut, H. (2023) Pulses of RhoA signaling stimulate actin polymerization and flow in protrusions to drive collective cell migration. Current biology : CB. 34(2):245-259.e8
- Love, A.M., Prince, D.J., Jessen, J.R. (2018) Vangl2-dependent regulation of membrane protrusions and directed migration requires a fibronectin extracellular matrix. Development (Cambridge, England). 145(22):
- Lozano-Ortega, M., Valera, G., Xiao, Y., Faucherre, A., López-Schier, H. (2018) Hair cell identity establishes labeled lines of directional mechanosensation. PLoS Biology. 16:e2004404
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ye, D., and Lin, F. (2013) S1pr2/Gα13 signaling controls myocardial migration by regulating endoderm convergence. Development (Cambridge, England). 140(4):789-799
- Lin, F., Chen, S., Sepich, D.S., Panizzi, J.R., Clendenon, S.G., Marrs, J.A., Hamm, H.E., and Solnica-Krezel, L. (2009) Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton. The Journal of cell biology. 184(6):909-921
- Panizzi, J.R., Jessen, J.R., Drummond, I.A., and Solnica-Krezel, L. (2007) New functions for a vertebrate Rho guanine nucleotide exchange factor in ciliated epithelia. Development (Cambridge, England). 134(5):921-931
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Lopez-Schier, H., and Hudspeth, A.J. (2006) A two-step mechanism underlies the planar polarization of regenerating sensory hair cells. Proceedings of the National Academy of Sciences of the United States of America. 103(49):18615-18620
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