Gene
nrxn2a
- ID
- ZDB-GENE-070206-5
- Name
- neurexin 2a
- Symbol
- nrxn2a Nomenclature History
- Previous Names
-
- nrxn2aa
- nrxn2ab
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Acts upstream of or within axon extension involved in axon guidance; chemical synaptic transmission; and motor neuron axon guidance. Predicted to be located in presynaptic membrane. Is expressed in nervous system and spinal cord neural tube. Orthologous to human NRXN2 (neurexin 2).
- Genome Resources
- Note
-
nrxn2a has two isoforms, alpha (DQ641428) and beta (DQ641429)
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010201Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la014047Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021939Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021940Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028338Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028340Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mn0435Gt | Transgenic insertion | Unknown | Unknown | DNA | |
| ns15 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa16817 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18390 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like domain | Laminin G domain | Neurexin-related cell adhesion and synaptic protein | Neurexin/syndecan/glycophorin C | Syndecan/Neurexin domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P3C3
|
1658 | ||||||
|
UniProtKB:A0A8M9PIB5
|
1638 | ||||||
|
UniProtKB:A0A8M9P3C5
|
1468 | ||||||
|
UniProtKB:A0A8M3AU05
|
1652 | ||||||
|
UniProtKB:A1XQX4
|
1670 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nrxn2a-201
(1)
|
Ensembl | 4,333 nt | ||
| mRNA |
nrxn2a-203
(1)
|
Ensembl | 6,930 nt | ||
| mRNA |
nrxn2a-204
(1)
|
Ensembl | 5,013 nt | ||
| ncRNA |
nrxn2a-003
(1)
|
Ensembl | 576 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-93G12 | ZFIN Curated Data | |
| Contained in | BAC | CH211-69J13 | ZFIN Curated Data | |
| Contained in | BAC | CH211-101J8 | ZFIN Curated Data | |
| Contained in | BAC | CH211-196O14 | ZFIN Curated Data | |
| Contained in | BAC | CH211-247J24 | ZFIN Curated Data | |
| Contained in | BAC | CH211-268G14 | ZFIN Curated Data | |
| Contained in | BAC | CH211-268L18 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-28P18 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001079970 (1) | 6930 nt | ||
| Genomic | GenBank:AL845282 (2) | 192865 nt | ||
| Polypeptide | UniProtKB:A1XQX4 (1) | 1670 aa |
- Pan, W., Godoy, R.S., Cook, D.P., Scott, A.L., Nurse, C.A., Jonz, M.G. (2022) Single-cell transcriptomic analysis of neuroepithelial cells and other cell types of the gills of zebrafish (Danio rerio) exposed to hypoxia. Scientific Reports. 12:10144
- Tromp, A., Robinson, K., Hall, T.E., Mowry, B., Giacomotto, J. (2021) Pipeline for generating stable large genomic deletions in zebrafish, from small domains to whole gene excisions. G3 (Bethesda). 11(12):
- Koh, A., Tao, S., Jing, G.Y., Chaganty, V., See, K., Purushothaman, K., Orbán, L., Mathuru, A.S., Wohland, T., Winkler, C. (2020) A Neurexin2aa deficiency results in axon pathfinding defects and increased anxiety in zebrafish. Human molecular genetics. 29(23):3765-3780
- Dragojević, J., Mihaljević, I., Popović, M., Smital, T. (2019) Zebrafish (Danio rerio) Oat1 and Oat3 transporters and their interaction with physiological compounds. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 236:110309
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Tu, H., Peng, T., Liu, J., Chen, X., Fan, C., Huang, Z., Zhang, Y., Zou, F., Meng, X. (2017) Role of neurexin2a in lead-induced locomotor defect in developing zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 194:167-175
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Mihaljevic, I., Popovic, M., Zaja, R., Smital, T. (2016) Phylogenetic, syntenic, and tissue expression analysis of slc22 genes in zebrafish (Danio rerio). BMC Genomics. 17:626
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Shah, A.N., Davey, C.F., Whitebirch, A.C., Miller, A.C., Moens, C.B. (2015) Rapid reverse genetic screening using CRISPR in zebrafish. Nature Methods. 12(6):535-40
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