ZFIN is now using GRCz12tu for Genomic Data
Gene
hdac4
- ID
- ZDB-GENE-061013-95
- Name
- histone deacetylase 4
- Symbol
- hdac4 Nomenclature History
- Previous Names
-
- wu:fa96d08
- wu:fc56f08
- zgc:152701
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable histone deacetylase activity. Acts upstream of or within several processes, including embryonic cranial skeleton morphogenesis; perichondral ossification; and regulation of neural crest formation. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including cranial neural crest cell; cranium; nervous system; optic vesicle; and trigeminal placode. Human ortholog(s) of this gene implicated in ataxia telangiectasia; eating disorder; and retinal degeneration. Orthologous to human HDAC4 (histone deacetylase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017636 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with central hypotonia and dysmorphic facies | 619797 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR023801 | Histone deacetylase domain |
| Domain | IPR024643 | Histone deacetylase, glutamine rich N-terminal domain |
| Family | IPR046949 | Histone deacetylase 4/5/7/9 |
| Homologous_superfamily | IPR023696 | Ureohydrolase domain superfamily |
| Homologous_superfamily | IPR037138 | Histone deacetylase domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Histone deacetylase 4/5/7/9 | Histone deacetylase domain | Histone deacetylase domain superfamily | Histone deacetylase, glutamine rich N-terminal domain | Ureohydrolase domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IAH0 | InterPro | 1052 | |||||
| UniProtKB:Q08BS8 | InterPro | 1023 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-hdac4 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
3 |
Plasmids
No data available
- Genome Browsers