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Gene

hdac4

ID
ZDB-GENE-061013-95
Name
histone deacetylase 4
Symbol
hdac4 Nomenclature History
Previous Names
  • wu:fa96d08
  • wu:fc56f08
  • zgc:152701
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to enable NAD-dependent histone deacetylase activity (H3-K14 specific) and metal ion binding activity. Acts upstream of or within animal organ development; perichondral ossification; and regulation of neural crest formation. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex. Is expressed in several structures, including cranial neural crest cell; cranium; nervous system; optic vesicle; and trigeminal placode. Human ortholog(s) of this gene implicated in ataxia telangiectasia; chromosome 2q37 deletion syndrome; eating disorder; and retinal degeneration. Orthologous to human HDAC4 (histone deacetylase 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hdac4 Human Ortholog
No data available
Associated With hdac4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR023801 Histone deacetylase domain
Domain IPR024643 Histone deacetylase, glutamine rich N-terminal domain
Family IPR000286 Histone deacetylase family
Family IPR017320 Histone deacetylase class II, eukaryotic
Family IPR033660 Histone deacetylase 4/7
Homologous_superfamily IPR023696 Ureohydrolase domain superfamily
Homologous_superfamily IPR037138 Histone deacetylase domain superfamily
Domain Details Per Protein
Protein Length Histone deacetylase 4/7 Histone deacetylase class II, eukaryotic Histone deacetylase domain Histone deacetylase domain superfamily Histone deacetylase family Histone deacetylase, glutamine rich N-terminal domain Ureohydrolase domain superfamily
UniProtKB:Q08BS8 1023
UniProtKB:F1QRR4 1023
UniProtKB:Q1L670 144
UniProtKB:Q2VC82 1023
UniProtKB:A0A0R4IAH0 1052
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-hdac4 polyclonal IgG Rabbit
  • WB
Santa Cruz Biotechnology, Inc.
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations