Gene
comp
- ID
- ZDB-GENE-060606-1
- Name
- cartilage oligomeric matrix protein
- Symbol
- comp Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within regulation of extracellular matrix organization and tendon development. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix. Is expressed in several structures, including heart primordium; musculature system; notochord outer sheath cell; tendon; and vertebra. Human ortholog(s) of this gene implicated in carpal tunnel syndrome 2; multiple epiphyseal dysplasia 1; osteochondrodysplasia; and pseudoachondroplasia. Orthologous to human COMP (cartilage oligomeric matrix protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7154332 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Forte-Gomez et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| carpal tunnel syndrome 2 | Alliance | Carpal tunnel syndrome 2 | 619161 |
| multiple epiphyseal dysplasia 1 | Alliance | Epiphyseal dysplasia, multiple, 1 | 132400 |
| pseudoachondroplasia | Alliance | Pseudoachondroplasia | 177170 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR008859 | Thrombospondin, C-terminal |
| Domain | IPR024665 | Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain |
| Domain | IPR039081 | Thrombospondin-5, coiled coil domain |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR028974 | TSP type-3 repeat |
| Homologous_superfamily | IPR046970 | Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain superfamily |
| Repeat | IPR003367 | Thrombospondin, type 3-like repeat |
| Repeat | IPR017897 | Thrombospondin, type 3 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | NOTCH1 EGF-like calcium-binding domain | Thrombospondin-5, coiled coil domain | Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain | Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain superfamily | Thrombospondin, C-terminal | Thrombospondin, type 3-like repeat | Thrombospondin, type 3 repeat | TSP type-3 repeat |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z914 | InterPro | 748 | ||||||||||||
| UniProtKB:A0A0G2KDJ5 | InterPro | 749 |
Interactions and Pathways
No data available
Plasmids
No data available