Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-060503-341
Gene Name: DOT1-like, histone H3 methyltransferase (S. cerevisiae)
Gene Symbol: dot1l
Previous Names: si:dkey-211f22.1
Nomenclature History
GENE EXPRESSION
All Expression Data: Fig. 7 from Mahmoudi et al., 2010
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  hindbrain, intestine, midbrain
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 1 genotype
Alleles: sa1413
Knockdown reagents: MO1-dot1l (1), MO2-dot1l (1)
PHENOTYPE No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process canonical Wnt receptor signaling pathway (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR013110 (1)
  • InterPro:IPR017956 (1)
  • InterPro:IPR025789 (1)
  • PROSITE:PS51569 (1)
  • Pfam:PF08123 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA dot1l-001 (1) 3593
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM dot1l No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    dot1l Contained in: [BAC] DKEY-211F22 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001919746 (1) 4450 bp
    Genomic GenBank:AL773593 (1) 202726 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1Q4W7 (1) 1523 aa
    Sequence Clusters UniGene:133350 (1)
    Sequence Information (all 13)
    OTHER dot1l GENE PAGES
  • Gene:559945 (1)
  • VEGA:OTTDARG00000014160 (1)
  • Ensembl(Zv9):ENSDARG00000061992 (1)
  • MAPPING INFORMATION
    Chr: 22 Details
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish dot1l 22  
    Human DOT1L 19 (19p13.3)
  • OMIM:607375
  • Gene:84444
  • Mouse Dot1l 10 ( 39.72)
  • MGI:2143886
  • Gene:208266
  • CITATIONS (9)