Gene
slc39a3
- ID
- ZDB-GENE-060315-9
- Name
- solute carrier family 39 member 3
- Symbol
- slc39a3 Nomenclature History
- Previous Names
-
- wu:fc84e09
- zgc:158334
- ZIP3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable zinc ion transmembrane transporter activity. Acts upstream of or within response to zinc ion. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including SLC39A1 (solute carrier family 39 member 1).
- Genome Resources
-
- Alliance (1)
- Gene:792986 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
-
- GEO (1) Expression Atlas (1) Single Cell Expression Atlas (1) Daniocell (1)
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR003689 | Zinc/iron permease |
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Domain Details Per Protein
| Protein | Length | Zinc/iron permease |
|---|---|---|
|
UniProtKB:A0A0R4IDS1
|
||
|
UniProtKB:A1L1T6
|
290 |
1 - 2 of 2
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance
- He, X., Ge, C., Xia, J., Xia, Z., Zhao, L., Huang, S., Wang, R., Pan, J., Cheng, T., Xu, P.F., Wang, F., Min, J. (2023) The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 10(17):e2205345
- Kong, N., Zhao, Q., Liu, C., Li, J., Liu, Z., Gao, L., Wang, L., Song, L. (2020) The involvement of zinc transporters in the zinc accumulation in the Pacific oyster Crassostrea gigas. Gene. 750:144759
- Viana, J., Wildman, N., Hannon, E., Farbos, A., Neill, P.O., Moore, K., van Aerle, R., Paull, G., Santos, E., Mill, J. (2020) Clozapine-induced transcriptional changes in the zebrafish brain. NPJ schizophrenia. 6:3
- Zhao, L., Tan, J., Li, D., Jiang, L., Li, T., Yang, Y., Wang, G., Shang, Z., Wang, J., Zhou, J. (2019) SLC39A6/ZIP6 is essential for zinc homeostasis and T-cell development in zebrafish. Biochemical and Biophysical Research Communications. 511(4):896-902
- Beaver, L.M., Truong, L., Barton, C.L., Chase, T.T., Gonnerman, G.D., Wong, C.P., Tanguay, R.L., Ho, E. (2017) Combinatorial effects of zinc deficiency and arsenic exposure on zebrafish (Danio rerio) development. PLoS One. 12:e0183831
- Zhu, L.Y., Lin, A.F., Shao, T., Nie, L., Dong, W.R., Xiang, L.X., and Shao, J.Z. (2014) B cells in teleost fish act as pivotal initiating APCs in priming adaptive immunity: an evolutionary perspective on the origin of the B-1 cell subset and B7 molecules. Journal of immunology (Baltimore, Md. : 1950). 192(6):2699-2714
- Ho, E., Dukovcic, S., Hobson, B., Wong, C.P., Miller, G., Hardin, K., Traber, M.G., and Tanguay, R.L. (2012) Zinc transporter expression in zebrafish (Danio rerio) during development. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 155(1):26-32
- Yan, G., Zhang, Y., Yu, J., Yu, Y., Zhang, F., Zhang, Z., Wu, A., Yan, X., Zhou, Y., and Wang, F. (2012) Slc39a7/zip7 Plays a Critical Role in Development and Zinc Homeostasis in Zebrafish. PLoS One. 7(8):e42939
- Zheng, D., Feeney, G.P., Kille, P., and Hogstrand, C. (2008) Regulation of ZIP and ZnT zinc transporters in zebrafish gill: zinc repression of ZIP10 transcription by an intronic MRE cluster. Physiological Genomics. 34(2):205-214
- Feeney, G.P., Zheng, D., Kille, P., and Hogstrand. C. (2005) The phylogeny of teleost ZIP and ZnT zinc transporters and their tissue specific expression and response to zinc in zebrafish. BBA Gene Structure and Expression. 1732(1-3):88-95
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