Gene
slc30a8
- ID
- ZDB-GENE-060315-10
- Name
- solute carrier family 30 member 8
- Symbol
- slc30a8 Nomenclature History
- Previous Names
-
- wu:fe49g03
- ZnT8 (1)
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable zinc ion transmembrane transporter activity. Acts upstream of or within glucose homeostasis and type B pancreatic cell development. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SLC30A8 (solute carrier family 30 member 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from O'Hare et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu1798 | Allele with one point mutation | Exon 5 | Missense | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Diabetes mellitus, noninsulin-dependent, susceptibility to} | 125853 |
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Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc30a8-201
(1)
|
Ensembl | 3,839 nt | ||
| mRNA |
slc30a8-202
(1)
|
Ensembl | 1,149 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-49O18 | ZFIN Curated Data | |
| Encodes | EST | fe49g03 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068215337 (1) | 8110 nt | ||
| Genomic | GenBank:CU856423 (1) | 117903 nt | ||
| Polypeptide | RefSeq:XP_068071438 (1) |
- Abrar, M., Ali, S., Hussain, I., Khatoon, H., Batool, F., Ghazanfar, S., Corcoran, D., Kawakami, Y., Abbasi, A.A. (2024) Cis-regulatory control of mammalian Trps1 gene expression. Journal of experimental zoology. Part B, Molecular and developmental evolution. 342(2):85-100
- Kim, I., Seok, S.H., Lee, H.Y. (2023) Development of a Zebrafish Larvae Model for Diabetic Heart Failure With Reduced Ejection Fraction. Korean circulation journal. 53:344634-46
- Zhao, L., Tan, J., Li, D., Jiang, L., Li, T., Yang, Y., Wang, G., Shang, Z., Wang, J., Zhou, J. (2019) SLC39A6/ZIP6 is essential for zinc homeostasis and T-cell development in zebrafish. Biochemical and Biophysical Research Communications. 511(4):896-902
- Beaver, L.M., Nkrumah-Elie, Y.M., Truong, L., Barton, C.L., Knecht, A.L., Gonnerman, G.D., Wong, C.P., Tanguay, R.L., Ho, E. (2017) Adverse effects of parental zinc deficiency on metal homeostasis and embryonic development in a zebrafish model. The Journal of Nutritional Biochemistry. 43:78-87
- Beaver, L.M., Truong, L., Barton, C.L., Chase, T.T., Gonnerman, G.D., Wong, C.P., Tanguay, R.L., Ho, E. (2017) Combinatorial effects of zinc deficiency and arsenic exposure on zebrafish (Danio rerio) development. PLoS One. 12:e0183831
- O'Hare, E.A., Yerges-Armstrong, L.M., Perry, J.A., Shuldiner, A.R., Zaghloul, N.A. (2016) Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. Molecular endocrinology (Baltimore, Md.). 30(4):429-45
- Zheng, D., Feeney, G.P., Handy, R.D., Hogstrand, C., and Kille, P. (2014) Uptake epithelia behave in a cell-centric and not systems homeostatic manner in response to zinc depletion and supplementation. Metallomics : integrated biometal science. 6(1):154-65
- Ho, E., Dukovcic, S., Hobson, B., Wong, C.P., Miller, G., Hardin, K., Traber, M.G., and Tanguay, R.L. (2012) Zinc transporter expression in zebrafish (Danio rerio) during development. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 155(1):26-32
- Yan, G., Zhang, Y., Yu, J., Yu, Y., Zhang, F., Zhang, Z., Wu, A., Yan, X., Zhou, Y., and Wang, F. (2012) Slc39a7/zip7 Plays a Critical Role in Development and Zinc Homeostasis in Zebrafish. PLoS One. 7(8):e42939
- Kambe, T., Suzuki, T., Nagao, M., and Yamaguchi-Iwai, Y. (2006) Sequence similarity and functional relationship among eukaryotic ZIP and CDF transporters. Genomics, proteomics & bioinformatics. 4(1):1-9
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