Gene

cnksr2a

ID

ZDB-GENE-060228-5

Name

connector enhancer of kinase suppressor of Ras 2a

Symbol

cnksr2a Nomenclature History

Previous Names

cnksr2

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to enable kinase activity. Predicted to act upstream of or within phosphorylation and regulation of signal transduction. Predicted to be located in cytoplasm and membrane. Human ortholog(s) of this gene implicated in syndromic X-linked mental retardation Hough type. Orthologous to human CNKSR2 (connector enhancer of kinase suppressor of Ras 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cnksr2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
syndromic X-linked mental retardation Hough type	Alliance	Intellectual developmental disorder, X-linked syndromic, Houge type	301008

Associated With cnksr2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001478	PDZ domain
Domain	IPR001660	Sterile alpha motif domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR010599	Connector enhancer of kinase suppressor of ras 2/3 domain
Domain	IPR017874	CRIC domain
Domain	IPR049628	CNK1-3, SAM domain
Family	IPR051566	Connector enhancer of kinase suppressor of Ras
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR013761	Sterile alpha motif/pointed domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily

Domain Details Per Protein

Protein	Length	CNK1-3, SAM domain	Connector enhancer of kinase suppressor of Ras	Connector enhancer of kinase suppressor of ras 2/3 domain	CRIC domain	PDZ domain	PDZ superfamily	PH-like domain superfamily	Pleckstrin homology domain	Sterile alpha motif domain	Sterile alpha motif/pointed domain superfamily
UniProtKB:A0A8M3B6Q4 InterPro	1032
UniProtKB:A0A8M3AZ62 InterPro	1024
UniProtKB:A0A8M6Z4T4 InterPro	1031
UniProtKB:A0A8M3AW25 InterPro	975
UniProtKB:A0A8M9PXZ0 InterPro	1034
UniProtKB:A0A8M9PUH1 InterPro	976
UniProtKB:A0A8M3APA0 InterPro	1025

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cnksr2a-201 (1) Ensembl	Ensembl	3,057 nt	Select Tool ZFIN BLAST
mRNA	cnksr2a-202 (1) Ensembl	Ensembl	2,050 nt	Select Tool ZFIN BLAST
mRNA	cnksr2a-203 (1) Ensembl	Ensembl	2,685 nt	Select Tool ZFIN BLAST
mRNA	cnksr2a-204 (1) Ensembl	Ensembl	1,959 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations