ZFIN is now using GRCz12tu for Genomic Data

Gene

atp5f1a

ID

ZDB-GENE-060201-1

Name

ATP synthase F1 subunit alpha

Symbol

atp5f1a Nomenclature History

Previous Names

atp5a1
atp5fa1 (1)
zgc:154103

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables lipoteichoic acid binding activity. Acts upstream of or within with a positive effect on defense response to bacterium. Predicted to be located in mitochondrial inner membrane. Predicted to be part of proton-transporting ATP synthase complex. Is expressed in several structures, including digestive system; fin; muscle; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 22; mitochondrial complex V (ATP synthase) deficiency nuclear type 4A; and mitochondrial complex V (ATP synthase) deficiency nuclear type 4B. Orthologous to human ATP5F1A (ATP synthase F1 subunit alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 8 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Xian et al., 2025
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With atp5f1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
combined oxidative phosphorylation deficiency 22	Alliance	?Combined oxidative phosphorylation deficiency 22	616045
mitochondrial complex V (ATP synthase) deficiency nuclear type 4A	Alliance	Mitochondrial complex V (ATP synthase) deficiency, nuclear type 4A	620358
mitochondrial complex V (ATP synthase) deficiency nuclear type 4B	Alliance	?Mitochondrial complex V (ATP synthase) deficiency, nuclear type 4B, encephalopathic type	615228

Associated With atp5f1a Via Experimental Models

Human Disease	Fish	Conditions	Citations
mitochondrial complex V (ATP synthase) deficiency nuclear type 4	ml3Tg + MO2-atp5f1a (AB)	control	Xian et al., 2025
mitochondrial complex V (ATP synthase) deficiency nuclear type 4	AB + MO2-atp5f1a	control	Xian et al., 2025

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR020003	ATPase, alpha/beta subunit, nucleotide-binding domain, active site
Domain	IPR000194	ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
Domain	IPR000793	ATP synthase, alpha subunit, C-terminal
Domain	IPR004100	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain
Domain	IPR033732	ATP synthase, F1 complex, alpha subunit nucleotide-binding domain
Family	IPR005294	ATP synthase, F1 complex, alpha subunit
Homologous_superfamily	IPR023366	ATP synthase subunit alpha, N-terminal domain-like superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036121	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily
Homologous_superfamily	IPR038376	ATP synthase, alpha subunit, C-terminal domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	ATPase, alpha/beta subunit, nucleotide-binding domain, active site	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily	ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain	ATP synthase, alpha subunit, C-terminal	ATP synthase, alpha subunit, C-terminal domain superfamily	ATP synthase, F1 complex, alpha subunit	ATP synthase, F1 complex, alpha subunit nucleotide-binding domain	ATP synthase subunit alpha, N-terminal domain-like superfamily	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q08BA1	InterPro	551

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	atp5fa1-201 (1) Ensembl	Ensembl		1,883 nt	Select Tool ZFIN BLAST
ncRNA	atp5a1-002 (1) Ensembl	Ensembl		440 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-atp5a1	monoclonal	atp5f1a	IgG2b , k	Mouse	WB	MitoSciences	3

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations