Gene

atp5fa1

ID
ZDB-GENE-060201-1
Name
ATP synthase F1 subunit alpha
Symbol
atp5fa1 Nomenclature History
Previous Names
  • atp5a1
  • zgc:154103
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to contribute to ATPase activity. Predicted to be involved in ATP synthesis coupled proton transport. Predicted to localize to plasma membrane and proton-transporting ATP synthase complex, catalytic core F(1). Is expressed in brain; male organism; myotome; pectoral fin; and pharyngeal arch 3-7. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 22 and mitochondrial complex V (ATP synthase) deficiency nuclear type 4. Orthologous to human ATP5F1A (ATP synthase F1 subunit alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With atp5fa1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
combined oxidative phosphorylation deficiency 22 Alliance ?Combined oxidative phosphorylation deficiency 22 616045
mitochondrial complex V (ATP synthase) deficiency nuclear type 4A Alliance Mitochondrial complex V (ATP synthase) deficiency, nuclear type 4A 620358
mitochondrial complex V (ATP synthase) deficiency nuclear type 4B Alliance ?Mitochondrial complex V (ATP synthase) deficiency, nuclear type 4B, encephalopathic type 615228
Associated With atp5fa1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active site
Domain IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
Domain IPR000793 ATP synthase, alpha subunit, C-terminal
Domain IPR004100 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain
Domain IPR033732 ATP synthase, F1 complex, alpha subunit nucleotide-binding domain
Family IPR005294 ATP synthase, F1 complex, alpha subunit
Homologous_superfamily IPR023366 ATP synthase subunit alpha, N-terminal domain-like superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036121 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily
Homologous_superfamily IPR038376 ATP synthase, alpha subunit, C-terminal domain superfamily
Domain Details Per Protein
Protein Length ATPase, alpha/beta subunit, nucleotide-binding domain, active site ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain ATP synthase, alpha subunit, C-terminal ATP synthase, alpha subunit, C-terminal domain superfamily ATP synthase, F1 complex, alpha subunit ATP synthase, F1 complex, alpha subunit nucleotide-binding domain ATP synthase subunit alpha, N-terminal domain-like superfamily P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q08BA1 551
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA atp5fa1-201 (1) Ensembl 1,883 nt
ncRNA atp5a1-002 (1) Ensembl 440 nt
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-atp5a1 monoclonal IgG2b , k Mouse
  • WB
MitoSciences
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations