Gene
hmgcrb
- ID
- ZDB-GENE-051108-1
- Name
- 3-hydroxy-3-methylglutaryl-CoA reductase b
- Symbol
- hmgcrb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable hydroxymethylglutaryl-CoA reductase (NADPH) activity. Acts upstream of or within circulatory system development; embryonic viscerocranium morphogenesis; and neural crest cell migration. Predicted to be located in endoplasmic reticulum; membrane; and peroxisome. Predicted to be active in endoplasmic reticulum membrane and peroxisomal membrane. Is expressed in liver; notochord; and polster. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; coronary artery disease (multiple); diabetes mellitus (multiple); muscular disease (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6912716 (1 image)
- IMAGE:6904727 (2 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la014029Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| s617 | Allele with one point mutation | Unknown | Missense | ENU |
1 - 2 of 2
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-hmgcrb | N/A | (3) |
| MO2-hmgcrb | N/A | Eisa-Beygi et al., 2013 |
| MO3-hmgcrb | N/A | Eisa-Beygi et al., 2013 |
1 - 3 of 3
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023076 | Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site |
| Domain | IPR000731 | Sterol-sensing domain |
| Domain | IPR053958 | HMGCR/SNAP/NPC1-like, sterol-sensing domain |
| Family | IPR002202 | Hydroxymethylglutaryl-CoA reductase, class I/II |
| Family | IPR004554 | Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type |
1 - 5 of 10 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | HMGCR/SNAP/NPC1-like, sterol-sensing domain | Hydroxymethylglutaryl-CoA reductase, class I/II | Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily | Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site | Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily | Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily | Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type | Hydroxymethylglutaryl-CoA reductase, metazoan | Hydroxymethylglutaryl-CoA reductase, N-terminal | Sterol-sensing domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q58ER2 | InterPro | 845 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hmgcrb-201
(1)
|
Ensembl | 3,424 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-149I8 | ||
| Encodes | EST | IMAGE:6904727 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:6912716 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:110746 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001014292 (1) | 3410 nt | ||
| Genomic | GenBank:CR318660 (2) | 162045 nt | ||
| Polypeptide | UniProtKB:Q58ER2 (1) | 845 aa |
- Yu, H.C., Bai, Q.R., Guo, J.J., Chen, M.Y., Wang, L., Tong, F.C., Zhang, S.L., Wu, J. (2024) Elucidating hydroxysafflor yellow A's multi-target mechanisms against alcoholic liver disease through integrative pharmacology. Phytomedicine : international journal of phytotherapy and phytopharmacology. 134:155956155956
- Zhang, F., Tang, C., Wang, J., Lin, T., Ge, W., He, C., Yang, C., Zuo, Z. (2024) Letrozole induced a polycystic ovary syndrome model in zebrafish by interfering with the hypothalamic-pituitary-gonadal axis. Environmental pollution (Barking, Essex : 1987). 347:123723
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Withers, S.E., Rowlands, C.F., Tapia, V.S., Hedley, F., Mosneag, I.E., Crilly, S., Rice, G.I., Badrock, A.P., Hayes, A., Allan, S.M., Briggs, T.A., Kasher, P.R. (2023) Characterization of a mutant samhd1 zebrafish model implicates dysregulation of cholesterol biosynthesis in Aicardi-Goutières syndrome. Frontiers in immunology. 14:11009671100967
- Zhang, Z.F., Song, T.T., Chen, J.F., Lv, G.Y. (2023) Recovery of a hypolipidemic polysaccharide from artificially cultivated Sanghuangporus vaninii with an effective method. Frontiers in nutrition. 9:10955561095556
- Aishwarya, V., Anand, T., Vairamuthu, S., Solaipriya, S., Sangaran, A., Satish, R., Sivaramakrishnan, V. (2021) Ameliorative role of ellagic acid against acute liver steatosis in adult zebrafish experimental model. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 247:109061
- McGruer, V., Tanabe, P., Vliet, S.M.F., Dasgupta, S., Qian, L., Volz, D.C., Schlenk, D. (2021) Effects of phenanthrene exposure on cholesterol homeostasis and cardiotoxicity in zebrafish embryos. Environmental toxicology and chemistry. 40(6):1586-1595
- Bhuiyan, M.N.H., Kang, H., Choi, J., Lim, S., Kho, Y., Choi, K. (2020) Effects of 3,4-dichloroaniline (3,4-DCA) and 4,4'-methylenedianiline (4,4'-MDA) on sex hormone regulation and reproduction of adult zebrafish (Danio rerio). Chemosphere. 269:128768
- Chen, J.W., Niu, X., King, M.J., Noedl, M.T., Tabin, C.J., Galloway, J.L. (2020) The mevalonate pathway is a critical regulator of tendon cell specification. Development (Cambridge, England). 147(12):
- Liu, Y.S., Yuan, M.H., Zhang, C.Y., Liu, H.M., Liu, J.R., Wei, A.L., Ye, Q., Zeng, B., Li, M.F., Guo, Y.P., Guo, L. (2020) Puerariae Lobatae radix flavonoids and puerarin alleviate alcoholic liver injury in zebrafish by regulating alcohol and lipid metabolism. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 134:111121
1 - 10 of 66
Show