Gene
fbxl18
- ID
- ZDB-GENE-050913-65
- Name
- F-box and leucine-rich repeat protein 18
- Symbol
- fbxl18 Nomenclature History
- Previous Names
-
- zgc:114102
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Acts upstream of or within sclerotome development. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL18 (F-box and leucine rich repeat protein 18).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:114102 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Lee et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa767 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9554 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19420 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39545 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | F-box domain | F-box/LRR-repeat protein 18, F-box domain | F-box/LRR-repeat protein 18, LRR domain | Leucine-rich repeat domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q4V8X1 | InterPro | 721 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fbxl18-201
(1)
|
Ensembl | 2,626 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-160D14 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:114102 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162850 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030245 (1) | 2643 nt | ||
| Genomic | GenBank:BX649405 (1) | 231915 nt | ||
| Polypeptide | UniProtKB:Q4V8X1 (1) | 721 aa |
- Witjes, L., Van Troys, M., Vandekerckhove, J., Vandepoele, K., Ampe, C. (2019) A new evolutionary model for the vertebrate actin family including two novel groups. Molecular phylogenetics and evolution. 141:106632
- Zhu, W., Xu, X., Wang, X., Liu, J. (2019) Reprogramming histone modification patterns to coordinate gene expression in early zebrafish embryos. BMC Genomics. 20:248
- Lee, W.J., Chatterjee, S., Yap, S.P., Lim, S.L., Xing, X., Kraus, P., Sun, W., Hu, X., Sivakamasundari, V., Chan, H.Y., Kolatkar, P.R., Prabhakar, S., Lufkin, T. (2017) An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos. BioMed Research International. 2017:8932583
- Zheng, H., Li, S., Wu, Z., Zhang, Y., Hu, S., Yan, Y., and Li, Y. (2011) Differential response of multiple zebrafish hepatic F-box protein genes to 17α-ethinylestradiol treatment. Journal of environmental sciences (China). 23(4):664-670
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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